Journal Article

DKFZ-2023-00308

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dietary intake of total, heme and non-heme iron and the risk of colorectal cancer in a European prospective cohort study.

Aglago, E. K. ; Cross, A. J. ; Riboli, E. ; Fedirko, V. ; Hughes, D. J. ; Fournier, A. ; Jakszyn, P. ; Freisling, H. ; Gunter, M. J. ; Dahm, C. C. ; Overvad, K. ; Tjønneland, A. ; Kyrø, C. ; Boutron-Ruault, M.-C. ; Rothwell, J. A. ; Severi, G. ; Katzke, V.DKFZ* ; Srour, B.DKFZ* ; Schulze, M. B. ; Wittenbecher, C. ; Palli, D. ; Sieri, S. ; Pasanisi, F. ; Tumino, R. ; Ricceri, F. ; Bueno-de-Mesquita, B. ; Derksen, J. W. G. ; Skeie, G. ; Jensen, T. E. ; Lukic, M. ; Sánchez, M.-J. ; Amiano, P. ; Colorado-Yohar, S. ; Barricarte, A. ; Ericson, U. ; van Guelpen, B. ; Papier, K. ; Knuppel, A. ; Casagrande, C. ; Huybrechts, I. ; Heath, A. K. ; Tsilidis, K. K. ; Jenab, M.

2023
Nature Publ. Group Edinburgh

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Please use a persistent id in citations: doi:10.1038/s41416-023-02164-7

Abstract: Iron is an essential micronutrient with differing intake patterns and metabolism between men and women. Epidemiologic evidence on the association of dietary iron and its heme and non-heme components with colorectal cancer (CRC) development is inconclusive.We examined baseline dietary questionnaire-assessed intakes of total, heme, and non-heme iron and CRC risk in the EPIC cohort. Sex-specific multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were computed using Cox regression. We modelled substitution of a 1 mg/day of heme iron intake with non-heme iron using the leave one-out method.Of 450,105 participants (318,680 women) followed for 14.2 ± 4.0 years, 6162 (3511 women) developed CRC. In men, total iron intake was not associated with CRC risk (highest vs. lowest quintile, HRQ5vs.Q1:0.88; 95%CI:0.73, 1.06). An inverse association was observed for non-heme iron (HRQ5vs.Q1:0.80, 95%CI:0.67, 0.96) whereas heme iron showed a non-significant association (HRQ5vs.Q1:1.10; 95%CI:0.96, 1.27). In women, CRC risk was not associated with intakes of total (HRQ5vs.Q1:1.11, 95%CI:0.94, 1.31), heme (HRQ5vs.Q1:0.95; 95%CI:0.84, 1.07) or non-heme iron (HRQ5vs.Q1:1.03, 95%CI:0.88, 1.20). Substitution of heme with non-heme iron demonstrated lower CRC risk in men (HR:0.94; 95%CI: 0.89, 0.99).Our findings suggest potential sex-specific CRC risk associations for higher iron consumption that may differ by dietary sources.

Note: 2023 Apr;128(8):1529-1540

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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