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| 001 | 267530 | ||
| 005 | 20240229154919.0 | ||
| 024 | 7 | _ | |a 10.1038/s41416-023-02164-7 |2 doi |
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| 100 | 1 | _ | |a Aglago, Elom K |0 0000-0002-0442-3284 |b 0 |
| 245 | _ | _ | |a Dietary intake of total, heme and non-heme iron and the risk of colorectal cancer in a European prospective cohort study. |
| 260 | _ | _ | |a Edinburgh |c 2023 |b Nature Publ. Group |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a 2023 Apr;128(8):1529-1540 |
| 520 | _ | _ | |a Iron is an essential micronutrient with differing intake patterns and metabolism between men and women. Epidemiologic evidence on the association of dietary iron and its heme and non-heme components with colorectal cancer (CRC) development is inconclusive.We examined baseline dietary questionnaire-assessed intakes of total, heme, and non-heme iron and CRC risk in the EPIC cohort. Sex-specific multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were computed using Cox regression. We modelled substitution of a 1 mg/day of heme iron intake with non-heme iron using the leave one-out method.Of 450,105 participants (318,680 women) followed for 14.2 ± 4.0 years, 6162 (3511 women) developed CRC. In men, total iron intake was not associated with CRC risk (highest vs. lowest quintile, HRQ5vs.Q1:0.88; 95%CI:0.73, 1.06). An inverse association was observed for non-heme iron (HRQ5vs.Q1:0.80, 95%CI:0.67, 0.96) whereas heme iron showed a non-significant association (HRQ5vs.Q1:1.10; 95%CI:0.96, 1.27). In women, CRC risk was not associated with intakes of total (HRQ5vs.Q1:1.11, 95%CI:0.94, 1.31), heme (HRQ5vs.Q1:0.95; 95%CI:0.84, 1.07) or non-heme iron (HRQ5vs.Q1:1.03, 95%CI:0.88, 1.20). Substitution of heme with non-heme iron demonstrated lower CRC risk in men (HR:0.94; 95%CI: 0.89, 0.99).Our findings suggest potential sex-specific CRC risk associations for higher iron consumption that may differ by dietary sources. |
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| 700 | 1 | _ | |a Cross, Amanda J |b 1 |
| 700 | 1 | _ | |a Riboli, Elio |0 0000-0001-6795-6080 |b 2 |
| 700 | 1 | _ | |a Fedirko, Veronika |b 3 |
| 700 | 1 | _ | |a Hughes, David J |b 4 |
| 700 | 1 | _ | |a Fournier, Agnes |b 5 |
| 700 | 1 | _ | |a Jakszyn, Paula |b 6 |
| 700 | 1 | _ | |a Freisling, Heinz |0 0000-0001-8648-4998 |b 7 |
| 700 | 1 | _ | |a Gunter, Marc J |b 8 |
| 700 | 1 | _ | |a Dahm, Christina C |0 0000-0003-0481-2893 |b 9 |
| 700 | 1 | _ | |a Overvad, Kim |b 10 |
| 700 | 1 | _ | |a Tjønneland, Anne |b 11 |
| 700 | 1 | _ | |a Kyrø, Cecilie |b 12 |
| 700 | 1 | _ | |a Boutron-Ruault, Marie-Christine |b 13 |
| 700 | 1 | _ | |a Rothwell, Joseph A |b 14 |
| 700 | 1 | _ | |a Severi, Gianluca |b 15 |
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| 700 | 1 | _ | |a Srour, Bernard |0 P:(DE-He78)0644671d309776d45e0fc705d1156cac |b 17 |
| 700 | 1 | _ | |a Schulze, Matthias B |b 18 |
| 700 | 1 | _ | |a Wittenbecher, Clemens |b 19 |
| 700 | 1 | _ | |a Palli, Domenico |0 0000-0002-5558-2437 |b 20 |
| 700 | 1 | _ | |a Sieri, Sabina |b 21 |
| 700 | 1 | _ | |a Pasanisi, Fabrizio |b 22 |
| 700 | 1 | _ | |a Tumino, Rosario |0 0000-0003-2666-414X |b 23 |
| 700 | 1 | _ | |a Ricceri, Fulvio |0 0000-0001-8749-9737 |b 24 |
| 700 | 1 | _ | |a Bueno-de-Mesquita, Bas |b 25 |
| 700 | 1 | _ | |a Derksen, Jeroen W G |b 26 |
| 700 | 1 | _ | |a Skeie, Guri |b 27 |
| 700 | 1 | _ | |a Jensen, Torill Enget |b 28 |
| 700 | 1 | _ | |a Lukic, Marko |b 29 |
| 700 | 1 | _ | |a Sánchez, Maria-Jose |b 30 |
| 700 | 1 | _ | |a Amiano, Pilar |b 31 |
| 700 | 1 | _ | |a Colorado-Yohar, Sandra |b 32 |
| 700 | 1 | _ | |a Barricarte, Aurelio |b 33 |
| 700 | 1 | _ | |a Ericson, Ulrika |b 34 |
| 700 | 1 | _ | |a van Guelpen, Bethany |b 35 |
| 700 | 1 | _ | |a Papier, Keren |b 36 |
| 700 | 1 | _ | |a Knuppel, Anika |b 37 |
| 700 | 1 | _ | |a Casagrande, Corinne |b 38 |
| 700 | 1 | _ | |a Huybrechts, Inge |0 0000-0003-3838-855X |b 39 |
| 700 | 1 | _ | |a Heath, Alicia K |0 0000-0001-6517-1300 |b 40 |
| 700 | 1 | _ | |a Tsilidis, Konstantinos K |0 0000-0002-8452-8472 |b 41 |
| 700 | 1 | _ | |a Jenab, Mazda |0 0000-0002-0573-1852 |b 42 |
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