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@ARTICLE{Rotkopf:267549,
      author       = {L. T. Rotkopf$^*$ and M. F. Froelich and P. Riffel and C.
                      H. Ziener$^*$ and C. Reid$^*$ and H.-P. Schlemmer$^*$ and S.
                      O. Schoenberg and I. Ayx},
      title        = {{I}nfluence of heart rate and heart rate variability on the
                      feasibility of ultra-fast, high-pitch coronary
                      photon-counting computed tomography angiography.},
      journal      = {The international journal of cardiovascular imaging},
      volume       = {39},
      number       = {5},
      issn         = {0167-9899},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer},
      reportid     = {DKFZ-2023-00327},
      pages        = {1065-1073},
      year         = {2023},
      note         = {#EA:E010# / 2023 May;39(5):1065-1073},
      abstract     = {Coronary computed tomography angiography has become a
                      mainstay in diagnosing coronary artery disease and is
                      increasingly used in screening symptomatic patients.
                      Recently, photon-counting computed tomography (PCCT) has
                      been introduced into clinical practice, offering higher
                      spatial and temporal resolution. As the applied radiation
                      dose is highly dependent on the choice of scan mode and is
                      lowest using the ultra-fast high-pitch (FLASH) mode,
                      guidelines for their application are needed. From a
                      retrospective study investigating the properties of a novel
                      photon-counting computed tomography, all patients who
                      underwent FLASH-mode PCCT angiography were selected between
                      January and April 2022. This resulted in a study population
                      of 46 men and 27 women. We recorded pre- and intrascan ECG
                      readings and calculated heart rate (maximum heart rate 73
                      bpm) as well heart rate variability (maximum HRV 37 bpm) as
                      measured by the standard deviation of the heart rate.
                      Diagnostic quality and motion artifacts scores were recorded
                      for each coronary artery segment by consensus between two
                      readers. We found a highly significant association between
                      heart rate variability and image quality (p < 0.001). The
                      heart rate itself was not independently associated with
                      image quality. Both heart rate and heart rate variability
                      were significantly associated with the presence of motion
                      artifacts in a combined model. Scan heart rate
                      variability-but not heart rate itself-is a highly
                      significant predictor of reduced image quality on high-pitch
                      coronary photon-counting computed tomography angiography.
                      This may be due to better scanner architecture and an
                      increased temporal resolution compared to conventional
                      energy-integrating detector computed tomography, which has
                      to be addressed in a comparison study in the future.},
      keywords     = {Dose reduction (Other) / FLASH mode (Other) / Heart rate
                      (Other) / Image quality (Other) / Photon-counting detector
                      CT (Other)},
      cin          = {E010 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36773035},
      doi          = {10.1007/s10554-023-02808-y},
      url          = {https://inrepo02.dkfz.de/record/267549},
}