Journal Article DKFZ-2023-00327

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Influence of heart rate and heart rate variability on the feasibility of ultra-fast, high-pitch coronary photon-counting computed tomography angiography.

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2023
Springer Dordrecht [u.a.]

The international journal of cardiovascular imaging 39(5), 1065-1073 () [10.1007/s10554-023-02808-y]
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Abstract: Coronary computed tomography angiography has become a mainstay in diagnosing coronary artery disease and is increasingly used in screening symptomatic patients. Recently, photon-counting computed tomography (PCCT) has been introduced into clinical practice, offering higher spatial and temporal resolution. As the applied radiation dose is highly dependent on the choice of scan mode and is lowest using the ultra-fast high-pitch (FLASH) mode, guidelines for their application are needed. From a retrospective study investigating the properties of a novel photon-counting computed tomography, all patients who underwent FLASH-mode PCCT angiography were selected between January and April 2022. This resulted in a study population of 46 men and 27 women. We recorded pre- and intrascan ECG readings and calculated heart rate (maximum heart rate 73 bpm) as well heart rate variability (maximum HRV 37 bpm) as measured by the standard deviation of the heart rate. Diagnostic quality and motion artifacts scores were recorded for each coronary artery segment by consensus between two readers. We found a highly significant association between heart rate variability and image quality (p < 0.001). The heart rate itself was not independently associated with image quality. Both heart rate and heart rate variability were significantly associated with the presence of motion artifacts in a combined model. Scan heart rate variability-but not heart rate itself-is a highly significant predictor of reduced image quality on high-pitch coronary photon-counting computed tomography angiography. This may be due to better scanner architecture and an increased temporal resolution compared to conventional energy-integrating detector computed tomography, which has to be addressed in a comparison study in the future.

Keyword(s): Dose reduction ; FLASH mode ; Heart rate ; Image quality ; Photon-counting detector CT

Classification:

Note: #EA:E010# / 2023 May;39(5):1065-1073

Contributing Institute(s):
  1. E010 Radiologie (E010)
  2. C060 Biostatistik (C060)
Research Program(s):
  1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2023
Database coverage:
Medline ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; DEAL Springer ; Essential Science Indicators ; IF < 5 ; JCR ; NationallizenzNationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection
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 Record created 2023-02-13, last modified 2024-02-29



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