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000271226 0247_ $$2doi$$a10.1016/j.ajcnut.2022.10.004
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000271226 041__ $$aEnglish
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000271226 1001_ $$aKaravasiloglou, Nena$$b0
000271226 245__ $$aPrediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts.
000271226 260__ $$aOxford$$bOxford University Press$$c2023
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000271226 520__ $$aHigher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk.To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies.Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95% CIs in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC; n-cases = 947, n-controls = 947) and the UK Biobank (UK-BB; n-cases = 2759, n-controls = 12,021) cohorts.In EPIC, nonalbumin-adjusted total serum calcium (a proxy of free calcium) was not associated with CRC (OR: 0.94; 95% CI: 0.85, 1.03; modeled as continuous variable, per 1 mg/dL increase), colon cancer (OR: 0.93; 95% CI: 0.82, 1.05) or rectal cancer (OR: 1.01; 95% CI: 0.84, 1.20) risk in the multivariable adjusted model. In the UK-BB, serum ionized calcium (free calcium, most active form) was inversely associated with the risk of CRC (OR: 0.85; 95% CI: 0.76, 0.95; per 1 mg/dL) and colon cancer (OR: 0.78; 95% CI: 0.68, 0.90), but not rectal cancer (OR: 1.02; 95% CI: 0.83, 1.24) in multivariable adjusted models. Meta-analysis of EPIC and UK-BB CRC risk estimates showed an inverse risk association for CRC in the multivariable adjusted model (OR: 0.90; 95%CI: 0.84, 0.97). In analyses by quintiles, in both cohorts, higher levels of serum calcium were associated with reduced CRC risk (EPIC: ORQ5vs.Q1: 0.69; 95% CI: 0.47, 1.00; P-trend = 0.03; UK-BB: ORQ5vs.Q1: 0.82; 95% CI: 0.72, 0.94; P-trend < 0.01). Analyses by anatomical subsite showed an inverse cancer risk association in the colon (EPIC: ORQ5vs.Q1: 0.63, 95% CI: 0.39, 1.02; P-trend = 0.05; UK-BB: ORQ5vs.Q1: 0.75; 95% CI: 0.64, 0.88; P-trend < 0.01) but not the rectum.In UK-BB, higher serum ionized calcium levels were inversely associated with CRC, but the risk was restricted to the colon. Total serum calcium showed a null association in EPIC. Additional prospective studies in other populations are needed to better investigate these associations.
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000271226 650_7 $$2Other$$acancer
000271226 650_7 $$2Other$$acohort
000271226 650_7 $$2Other$$acolorectal
000271226 650_7 $$2Other$$arisk
000271226 650_7 $$2Other$$aserum calcium
000271226 650_7 $$0SY7Q814VUP$$2NLM Chemicals$$aCalcium
000271226 650_2 $$2MeSH$$aHumans
000271226 650_2 $$2MeSH$$aProspective Studies
000271226 650_2 $$2MeSH$$aCalcium
000271226 650_2 $$2MeSH$$aColorectal Neoplasms: epidemiology
000271226 650_2 $$2MeSH$$aColorectal Neoplasms: etiology
000271226 650_2 $$2MeSH$$aNutritional Status
000271226 650_2 $$2MeSH$$aColonic Neoplasms
000271226 650_2 $$2MeSH$$aCase-Control Studies
000271226 650_2 $$2MeSH$$aRisk Factors
000271226 650_2 $$2MeSH$$aEurope: epidemiology
000271226 7001_ $$aHughes, David J$$b1
000271226 7001_ $$aMurphy, Neil$$b2
000271226 7001_ $$aSchomburg, Lutz$$b3
000271226 7001_ $$aSun, Qian$$b4
000271226 7001_ $$aSeher, Vartiter$$b5
000271226 7001_ $$aRohrmann, Sabine$$b6
000271226 7001_ $$aWeiderpass, Elisabete$$b7
000271226 7001_ $$aTjønneland, Anne$$b8
000271226 7001_ $$aOlsen, Anja$$b9
000271226 7001_ $$aOvervad, Kim$$b10
000271226 7001_ $$aBoutron-Ruault, Marie-Christine$$b11
000271226 7001_ $$aMancini, Francesca Romana$$b12
000271226 7001_ $$aMahamat-Saleh, Yahya$$b13
000271226 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b14$$udkfz
000271226 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b15
000271226 7001_ $$aSchulze, Matthias B$$b16
000271226 7001_ $$aTumino, Rosario$$b17
000271226 7001_ $$aPanico, Salvatore$$b18
000271226 7001_ $$aMasala, Giovanna$$b19
000271226 7001_ $$aPala, Valeria$$b20
000271226 7001_ $$aSacerdote, Carlotta$$b21
000271226 7001_ $$aDerksen, Jeroen W G$$b22
000271226 7001_ $$aSkeie, Guri$$b23
000271226 7001_ $$aHjartåker, Anette$$b24
000271226 7001_ $$aLasheras, Cristina$$b25
000271226 7001_ $$aAgudo, Antonio$$b26
000271226 7001_ $$aSánchez, Maria-José$$b27
000271226 7001_ $$aChirlaque, Maria-Dolores$$b28
000271226 7001_ $$aArdanaz, Eva$$b29
000271226 7001_ $$aAmiano, Pilar$$b30
000271226 7001_ $$aVan Guelpen, Bethany$$b31
000271226 7001_ $$aGylling, Björn$$b32
000271226 7001_ $$aBradbury, Kathryn E$$b33
000271226 7001_ $$aPapier, Keren$$b34
000271226 7001_ $$aFreisling, Heinz$$b35
000271226 7001_ $$aAglago, Elom K$$b36
000271226 7001_ $$aCross, Amanda J$$b37
000271226 7001_ $$aRiboli, Elio$$b38
000271226 7001_ $$aAune, Dagfinn$$b39
000271226 7001_ $$aGunter, Marc J$$b40
000271226 7001_ $$aJenab, Mazda$$b41
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