Journal Article

DKFZ-2023-00363

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts.

Karavasiloglou, N. ; Hughes, D. J. ; Murphy, N. ; Schomburg, L. ; Sun, Q. ; Seher, V. ; Rohrmann, S. ; Weiderpass, E. ; Tjønneland, A. ; Olsen, A. ; Overvad, K. ; Boutron-Ruault, M.-C. ; Mancini, F. R. ; Mahamat-Saleh, Y. ; Kaaks, R.DKFZ* ; Kühn, T.DKFZ* ; Schulze, M. B. ; Tumino, R. ; Panico, S. ; Masala, G. ; Pala, V. ; Sacerdote, C. ; Derksen, J. W. G. ; Skeie, G. ; Hjartåker, A. ; Lasheras, C. ; Agudo, A. ; Sánchez, M.-J. ; Chirlaque, M.-D. ; Ardanaz, E. ; Amiano, P. ; Van Guelpen, B. ; Gylling, B. ; Bradbury, K. E. ; Papier, K. ; Freisling, H. ; Aglago, E. K. ; Cross, A. J. ; Riboli, E. ; Aune, D. ; Gunter, M. J. ; Jenab, M.

2023
Oxford University Press Oxford

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Please use a persistent id in citations: doi:10.1016/j.ajcnut.2022.10.004

Abstract: Higher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk.To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies.Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95% CIs in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC; n-cases = 947, n-controls = 947) and the UK Biobank (UK-BB; n-cases = 2759, n-controls = 12,021) cohorts.In EPIC, nonalbumin-adjusted total serum calcium (a proxy of free calcium) was not associated with CRC (OR: 0.94; 95% CI: 0.85, 1.03; modeled as continuous variable, per 1 mg/dL increase), colon cancer (OR: 0.93; 95% CI: 0.82, 1.05) or rectal cancer (OR: 1.01; 95% CI: 0.84, 1.20) risk in the multivariable adjusted model. In the UK-BB, serum ionized calcium (free calcium, most active form) was inversely associated with the risk of CRC (OR: 0.85; 95% CI: 0.76, 0.95; per 1 mg/dL) and colon cancer (OR: 0.78; 95% CI: 0.68, 0.90), but not rectal cancer (OR: 1.02; 95% CI: 0.83, 1.24) in multivariable adjusted models. Meta-analysis of EPIC and UK-BB CRC risk estimates showed an inverse risk association for CRC in the multivariable adjusted model (OR: 0.90; 95%CI: 0.84, 0.97). In analyses by quintiles, in both cohorts, higher levels of serum calcium were associated with reduced CRC risk (EPIC: ORQ5vs.Q1: 0.69; 95% CI: 0.47, 1.00; P-trend = 0.03; UK-BB: ORQ5vs.Q1: 0.82; 95% CI: 0.72, 0.94; P-trend < 0.01). Analyses by anatomical subsite showed an inverse cancer risk association in the colon (EPIC: ORQ5vs.Q1: 0.63, 95% CI: 0.39, 1.02; P-trend = 0.05; UK-BB: ORQ5vs.Q1: 0.75; 95% CI: 0.64, 0.88; P-trend < 0.01) but not the rectum.In UK-BB, higher serum ionized calcium levels were inversely associated with CRC, but the risk was restricted to the colon. Total serum calcium showed a null association in EPIC. Additional prospective studies in other populations are needed to better investigate these associations.

Keyword(s): Humans (MeSH) ; Prospective Studies (MeSH) ; Calcium (MeSH) ; Colorectal Neoplasms: epidemiology (MeSH) ; Colorectal Neoplasms: etiology (MeSH) ; Nutritional Status (MeSH) ; Colonic Neoplasms (MeSH) ; Case-Control Studies (MeSH) ; Risk Factors (MeSH) ; Europe: epidemiology (MeSH) ; cancer ; cohort ; colorectal ; risk ; serum calcium ; Calcium

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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