%0 Journal Article
%A Gkika, Eleni
%A Firat, Elke
%A Adebahr, Sonja
%A Graf, Erika
%A Popp, Ilinca
%A Radicioni, Gianluca
%A Lo, Simon S
%A Nestle, Ursula
%A Nicolay, Nils
%A Niedermann, Gabriele
%A Duda, Dan G
%A Grosu, Anca-L
%T Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer.
%J npj precision oncology
%V 7
%N 1
%@ 2397-768X
%C [London]
%I Springer Nature
%M DKFZ-2023-00434
%P 24
%D 2023
%X We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8+ cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67+CD8+ and Ki-67+CD4+ T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36864234
%R 10.1038/s41698-023-00358-z
%U https://inrepo02.dkfz.de/record/274101