Journal Article

DKFZ-2023-00434

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer.

Gkika, E.DKFZ* ; Firat, E.DKFZ* ; Adebahr, S.DKFZ* ; Graf, E. ; Popp, I.DKFZ* ; Radicioni, G.DKFZ* ; Lo, S. S. ; Nestle, U. ; Nicolay, N.DKFZ* ; Niedermann, G.DKFZ* ; Duda, D. G. ; Grosu, A.-L.DKFZ*

2023
Springer Nature [London]

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Please use a persistent id in citations: doi:10.1038/s41698-023-00358-z

Abstract: We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8+ cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67+CD8+ and Ki-67+CD4+ T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment.

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Freiburg (FR01)
2. E055 KKE Molekulare Radioonkologie (E055)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2023

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