TY  - JOUR
AU  - Gkika, Eleni
AU  - Firat, Elke
AU  - Adebahr, Sonja
AU  - Graf, Erika
AU  - Popp, Ilinca
AU  - Radicioni, Gianluca
AU  - Lo, Simon S
AU  - Nestle, Ursula
AU  - Nicolay, Nils
AU  - Niedermann, Gabriele
AU  - Duda, Dan G
AU  - Grosu, Anca-L
TI  - Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer.
JO  - npj precision oncology
VL  - 7
IS  - 1
SN  - 2397-768X
CY  - [London]
PB  - Springer Nature
M1  - DKFZ-2023-00434
SP  - 24
PY  - 2023
AB  - We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8+ cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67+CD8+ and Ki-67+CD4+ T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment.
LB  - PUB:(DE-HGF)16
C6  - pmid:36864234
DO  - DOI:10.1038/s41698-023-00358-z
UR  - https://inrepo02.dkfz.de/record/274101
ER  -