%0 Journal Article
%A Brühlmann, Santiago Andrés
%A Walther, Martin
%A Kreller, Martin
%A Reissig, Falco
%A Pietzsch, Hans-Jürgen
%A Kniess, Torsten
%A Kopka, Klaus
%T Cyclotron-Based Production of 67Cu for Radionuclide Theranostics via the 70Zn(p,α)67Cu Reaction
%J Pharmaceuticals
%V 16
%N 2
%@ 1424-8247
%C Basel
%I MDPI
%M DKFZ-2023-00445
%P 314
%D 2023
%X Theranostic matched pairs of radionuclides have aroused interest during the last couple ofyears, and in that sense, copper is one element that has a lot to offer, and although 61Cu and 64Cu areslowly being established as diagnostic radionuclides for PET, the availability of the therapeutic counterpart 67Cu plays a key role for further radiopharmaceutical development in the future. Until now,the 67Cu shortage has not been solved; however, different production routes are being explored. Thisproject aims at the production of no-carrier-added 67Cu with high radionuclidic purity with a medical30 MeV compact cyclotron via the 70Zn(p,α)67Cu reaction. With this purpose, proton irradiation ofelectrodeposited 70Zn targets was performed followed by two-step radiochemical separation based onsolid-phase extraction. Activities of up to 600 MBq 67Cu at end of bombardment, with radionuclidicpurities over 99.5
%F PUB:(DE-HGF)16
%9 Journal Article
%R 10.3390/ph16020314
%U https://inrepo02.dkfz.de/record/274135