Journal Article

DKFZ-2023-00445

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cyclotron-Based Production of 67Cu for Radionuclide Theranostics via the 70Zn(p,α)67Cu Reaction

Brühlmann, S. A. ; Walther, M. ; Kreller, M. ; Reissig, F. ; Pietzsch, H.-J. ; Kniess, T. ; Kopka, K.DKFZ*

2023
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/ph16020314

Abstract: Theranostic matched pairs of radionuclides have aroused interest during the last couple ofyears, and in that sense, copper is one element that has a lot to offer, and although 61Cu and 64Cu areslowly being established as diagnostic radionuclides for PET, the availability of the therapeutic counterpart 67Cu plays a key role for further radiopharmaceutical development in the future. Until now,the 67Cu shortage has not been solved; however, different production routes are being explored. Thisproject aims at the production of no-carrier-added 67Cu with high radionuclidic purity with a medical30 MeV compact cyclotron via the 70Zn(p,α)67Cu reaction. With this purpose, proton irradiation ofelectrodeposited 70Zn targets was performed followed by two-step radiochemical separation based onsolid-phase extraction. Activities of up to 600 MBq 67Cu at end of bombardment, with radionuclidicpurities over 99.5% and apparent molar activities of up to 80 MBq/nmol, were quantified.

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Contributing Institute(s):

1. DKTK DD zentral (DD01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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