TY  - JOUR
AU  - Brühlmann, Santiago Andrés
AU  - Walther, Martin
AU  - Kreller, Martin
AU  - Reissig, Falco
AU  - Pietzsch, Hans-Jürgen
AU  - Kniess, Torsten
AU  - Kopka, Klaus
TI  - Cyclotron-Based Production of 67Cu for Radionuclide Theranostics via the 70Zn(p,α)67Cu Reaction
JO  - Pharmaceuticals
VL  - 16
IS  - 2
SN  - 1424-8247
CY  - Basel
PB  - MDPI
M1  - DKFZ-2023-00445
SP  - 314
PY  - 2023
AB  - Theranostic matched pairs of radionuclides have aroused interest during the last couple ofyears, and in that sense, copper is one element that has a lot to offer, and although 61Cu and 64Cu areslowly being established as diagnostic radionuclides for PET, the availability of the therapeutic counterpart 67Cu plays a key role for further radiopharmaceutical development in the future. Until now,the 67Cu shortage has not been solved; however, different production routes are being explored. Thisproject aims at the production of no-carrier-added 67Cu with high radionuclidic purity with a medical30 MeV compact cyclotron via the 70Zn(p,α)67Cu reaction. With this purpose, proton irradiation ofelectrodeposited 70Zn targets was performed followed by two-step radiochemical separation based onsolid-phase extraction. Activities of up to 600 MBq 67Cu at end of bombardment, with radionuclidicpurities over 99.5
LB  - PUB:(DE-HGF)16
DO  - DOI:10.3390/ph16020314
UR  - https://inrepo02.dkfz.de/record/274135
ER  -