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@ARTICLE{Brhlmann:274135,
      author       = {S. A. Brühlmann and M. Walther and M. Kreller and F.
                      Reissig and H.-J. Pietzsch and T. Kniess and K. Kopka$^*$},
      title        = {{C}yclotron-{B}ased {P}roduction of 67{C}u for
                      {R}adionuclide {T}heranostics via the 70{Z}n(p,α)67{C}u
                      {R}eaction},
      journal      = {Pharmaceuticals},
      volume       = {16},
      number       = {2},
      issn         = {1424-8247},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-00445},
      pages        = {314},
      year         = {2023},
      abstract     = {Theranostic matched pairs of radionuclides have aroused
                      interest during the last couple ofyears, and in that sense,
                      copper is one element that has a lot to offer, and although
                      61Cu and 64Cu areslowly being established as diagnostic
                      radionuclides for PET, the availability of the therapeutic
                      counterpart 67Cu plays a key role for further
                      radiopharmaceutical development in the future. Until now,the
                      67Cu shortage has not been solved; however, different
                      production routes are being explored. Thisproject aims at
                      the production of no-carrier-added 67Cu with high
                      radionuclidic purity with a medical30 MeV compact cyclotron
                      via the 70Zn(p,α)67Cu reaction. With this purpose, proton
                      irradiation ofelectrodeposited 70Zn targets was performed
                      followed by two-step radiochemical separation based
                      onsolid-phase extraction. Activities of up to 600 MBq 67Cu
                      at end of bombardment, with radionuclidicpurities over
                      $99.5\%$ and apparent molar activities of up to 80 MBq/nmol,
                      were quantified.},
      cin          = {DD01},
      ddc          = {610},
      cid          = {I:(DE-He78)DD01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.3390/ph16020314},
      url          = {https://inrepo02.dkfz.de/record/274135},
}