000274148 001__ 274148
000274148 005__ 20240229154927.0
000274148 0247_ $$2doi$$a10.1002/hed.27298
000274148 0247_ $$2pmid$$apmid:36872620
000274148 0247_ $$2ISSN$$a0148-6403
000274148 0247_ $$2ISSN$$a1043-3074
000274148 0247_ $$2ISSN$$a1097-0347
000274148 0247_ $$2ISSN$$a1930-2398
000274148 0247_ $$2altmetric$$aaltmetric:143237539
000274148 037__ $$aDKFZ-2023-00458
000274148 041__ $$aEnglish
000274148 082__ $$a610
000274148 1001_ $$aRegnery, Sebastian$$b0
000274148 245__ $$aTumor treating fields as novel combination partner in the multimodal treatment of head and neck cancer.
000274148 260__ $$aNew York, NY [u.a.]$$bWiley Interscience$$c2023
000274148 3367_ $$2DRIVER$$aarticle
000274148 3367_ $$2DataCite$$aOutput Types/Journal article
000274148 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1687854407_19594
000274148 3367_ $$2BibTeX$$aARTICLE
000274148 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000274148 3367_ $$00$$2EndNote$$aJournal Article
000274148 500__ $$a#LA:E055# / 2023 Apr;45(4):838-848
000274148 520__ $$aWe aimed to demonstrate the effects of tumor treating fields (TTFields) in head and neck squamous cell carcinoma (HNSCC) cells when combined with radiotherapy (RT) and chemotherapy.Two human HNSCC cell lines (Cal27, FaDu) received five different treatments: TTFields, RT +/- TTFields and RT + simultaneous cisplatin +/- TTFields. Effects were quantified using clonogenic assays and flow cytometric analyses of DAPI, caspase-3 activation and γH2AX foci.Treatment with RT + TTFields decreased the clonogenic survival as strong as treatment with RT + simultaneous cisplatin. The triple combination of RT + simultaneous cisplatin + TTFields even further decreased the clonogenic survival. Accordingly, combination of TTFields with RT or RT + simultaneous cisplatin increased cellular apoptosis and DNA double-strand breaks.TTFields therapy seems a promising combination partner in the multimodal treatment of locally advanced HNSCC. It could be used to intensify chemoradiotherapy or as alternative to chemotherapy.
000274148 536__ $$0G:(DE-HGF)POF4-315$$a315 - Bildgebung und Radioonkologie (POF4-315)$$cPOF4-315$$fPOF IV$$x0
000274148 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000274148 650_7 $$2Other$$achemoradiotherapy
000274148 650_7 $$2Other$$ahead and neck cancer
000274148 650_7 $$2Other$$aradiotherapy
000274148 650_7 $$2Other$$asquamous cell carcinoma of head and neck
000274148 650_7 $$2Other$$atumor treating fields
000274148 7001_ $$0P:(DE-HGF)0$$aFranke, Henrik$$b1
000274148 7001_ $$0P:(DE-He78)cbbd83b83a83176c38ba2c45ac072a3d$$aHeld, Thomas$$b2
000274148 7001_ $$0P:(DE-HGF)0$$aTrinh, Thuy$$b3
000274148 7001_ $$aNaveh, Ariel$$b4
000274148 7001_ $$aAbraham, Yissachar$$b5
000274148 7001_ $$0P:(DE-He78)c59ff25b48c192ed3fd4ad3a4bc9b9c0$$aHörner-Rieber, Juliane$$b6$$udkfz
000274148 7001_ $$0P:(DE-He78)2e5f34f1c58eda4787a14c9dc139ca5f$$aHess, Jochen$$b7$$udkfz
000274148 7001_ $$0P:(DE-He78)3291aaac20f3d603d96744c1f0890028$$aHuber, Peter$$b8$$udkfz
000274148 7001_ $$0P:(DE-He78)8714da4e45acfa36ce87c291443a9218$$aDebus, Jürgen$$b9$$udkfz
000274148 7001_ $$0P:(DE-He78)c5a1a98649a7874de0def093eb136262$$aLopez Perez, Ramon$$b10$$udkfz
000274148 7001_ $$00000-0001-8463-514X$$aAdeberg, Sebastian$$b11$$eLast author
000274148 773__ $$0PERI:(DE-600)2001440-5$$a10.1002/hed.27298$$gp. hed.27298$$n4$$p838-848$$tHead & neck$$v45$$x0148-6403$$y2023
000274148 909CO $$ooai:inrepo02.dkfz.de:274148$$pVDB
000274148 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000274148 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)cbbd83b83a83176c38ba2c45ac072a3d$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000274148 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000274148 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c59ff25b48c192ed3fd4ad3a4bc9b9c0$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000274148 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)2e5f34f1c58eda4787a14c9dc139ca5f$$aDeutsches Krebsforschungszentrum$$b7$$kDKFZ
000274148 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3291aaac20f3d603d96744c1f0890028$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000274148 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)8714da4e45acfa36ce87c291443a9218$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000274148 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c5a1a98649a7874de0def093eb136262$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000274148 9101_ $$0I:(DE-588b)2036810-0$$60000-0001-8463-514X$$aDeutsches Krebsforschungszentrum$$b11$$kDKFZ
000274148 9131_ $$0G:(DE-HGF)POF4-315$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vBildgebung und Radioonkologie$$x0
000274148 9141_ $$y2023
000274148 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2022-11-16$$wger
000274148 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2022-11-16
000274148 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2022-11-16
000274148 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2022-11-16
000274148 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2023-08-26$$wger
000274148 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-26
000274148 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-26
000274148 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-26
000274148 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-26
000274148 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-26
000274148 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2023-08-26
000274148 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bHEAD NECK-J SCI SPEC : 2022$$d2023-08-26
000274148 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-08-26
000274148 9202_ $$0I:(DE-He78)E055-20160331$$kE055$$lE055 KKE Molekulare Radioonkologie$$x0
000274148 9201_ $$0I:(DE-He78)E055-20160331$$kE055$$lE055 KKE Molekulare Radioonkologie$$x0
000274148 9201_ $$0I:(DE-He78)E221-20160331$$kE221$$lMolekulare Grundlagen von HNO-Tumoren$$x1
000274148 980__ $$ajournal
000274148 980__ $$aVDB
000274148 980__ $$aI:(DE-He78)E055-20160331
000274148 980__ $$aI:(DE-He78)E221-20160331
000274148 980__ $$aUNRESTRICTED