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| Home > Publications database > Tumor treating fields as novel combination partner in the multimodal treatment of head and neck cancer. |
| Journal Article | DKFZ-2023-00458 |
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2023
Wiley Interscience
New York, NY [u.a.]
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Please use a persistent id in citations: doi:10.1002/hed.27298
Abstract: We aimed to demonstrate the effects of tumor treating fields (TTFields) in head and neck squamous cell carcinoma (HNSCC) cells when combined with radiotherapy (RT) and chemotherapy.Two human HNSCC cell lines (Cal27, FaDu) received five different treatments: TTFields, RT +/- TTFields and RT + simultaneous cisplatin +/- TTFields. Effects were quantified using clonogenic assays and flow cytometric analyses of DAPI, caspase-3 activation and γH2AX foci.Treatment with RT + TTFields decreased the clonogenic survival as strong as treatment with RT + simultaneous cisplatin. The triple combination of RT + simultaneous cisplatin + TTFields even further decreased the clonogenic survival. Accordingly, combination of TTFields with RT or RT + simultaneous cisplatin increased cellular apoptosis and DNA double-strand breaks.TTFields therapy seems a promising combination partner in the multimodal treatment of locally advanced HNSCC. It could be used to intensify chemoradiotherapy or as alternative to chemotherapy.
Keyword(s): chemoradiotherapy ; head and neck cancer ; radiotherapy ; squamous cell carcinoma of head and neck ; tumor treating fields
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