TY  - JOUR
AU  - Regnery, Sebastian
AU  - Franke, Henrik
AU  - Held, Thomas
AU  - Trinh, Thuy
AU  - Naveh, Ariel
AU  - Abraham, Yissachar
AU  - Hörner-Rieber, Juliane
AU  - Hess, Jochen
AU  - Huber, Peter
AU  - Debus, Jürgen
AU  - Lopez Perez, Ramon
AU  - Adeberg, Sebastian
TI  - Tumor treating fields as novel combination partner in the multimodal treatment of head and neck cancer.
JO  - Head & neck
VL  - 45
IS  - 4
SN  - 0148-6403
CY  - New York, NY [u.a.]
PB  - Wiley Interscience
M1  - DKFZ-2023-00458
SP  - 838-848
PY  - 2023
N1  - #LA:E055# / 2023 Apr;45(4):838-848
AB  - We aimed to demonstrate the effects of tumor treating fields (TTFields) in head and neck squamous cell carcinoma (HNSCC) cells when combined with radiotherapy (RT) and chemotherapy.Two human HNSCC cell lines (Cal27, FaDu) received five different treatments: TTFields, RT +/- TTFields and RT + simultaneous cisplatin +/- TTFields. Effects were quantified using clonogenic assays and flow cytometric analyses of DAPI, caspase-3 activation and γH2AX foci.Treatment with RT + TTFields decreased the clonogenic survival as strong as treatment with RT + simultaneous cisplatin. The triple combination of RT + simultaneous cisplatin + TTFields even further decreased the clonogenic survival. Accordingly, combination of TTFields with RT or RT + simultaneous cisplatin increased cellular apoptosis and DNA double-strand breaks.TTFields therapy seems a promising combination partner in the multimodal treatment of locally advanced HNSCC. It could be used to intensify chemoradiotherapy or as alternative to chemotherapy.
KW  - chemoradiotherapy (Other)
KW  - head and neck cancer (Other)
KW  - radiotherapy (Other)
KW  - squamous cell carcinoma of head and neck (Other)
KW  - tumor treating fields (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36872620
DO  - DOI:10.1002/hed.27298
UR  - https://inrepo02.dkfz.de/record/274148
ER  -