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@ARTICLE{Regnery:274148,
      author       = {S. Regnery and H. Franke$^*$ and T. Held$^*$ and T.
                      Trinh$^*$ and A. Naveh and Y. Abraham and J.
                      Hörner-Rieber$^*$ and J. Hess$^*$ and P. Huber$^*$ and J.
                      Debus$^*$ and R. Lopez Perez$^*$ and S. Adeberg$^*$},
      title        = {{T}umor treating fields as novel combination partner in the
                      multimodal treatment of head and neck cancer.},
      journal      = {Head $\&$ neck},
      volume       = {45},
      number       = {4},
      issn         = {0148-6403},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley Interscience},
      reportid     = {DKFZ-2023-00458},
      pages        = {838-848},
      year         = {2023},
      note         = {#LA:E055# / 2023 Apr;45(4):838-848},
      abstract     = {We aimed to demonstrate the effects of tumor treating
                      fields (TTFields) in head and neck squamous cell carcinoma
                      (HNSCC) cells when combined with radiotherapy (RT) and
                      chemotherapy.Two human HNSCC cell lines (Cal27, FaDu)
                      received five different treatments: TTFields, RT +/-
                      TTFields and RT + simultaneous cisplatin +/- TTFields.
                      Effects were quantified using clonogenic assays and flow
                      cytometric analyses of DAPI, caspase-3 activation and γH2AX
                      foci.Treatment with RT + TTFields decreased the clonogenic
                      survival as strong as treatment with RT + simultaneous
                      cisplatin. The triple combination of RT + simultaneous
                      cisplatin + TTFields even further decreased the clonogenic
                      survival. Accordingly, combination of TTFields with RT or RT
                      + simultaneous cisplatin increased cellular apoptosis and
                      DNA double-strand breaks.TTFields therapy seems a promising
                      combination partner in the multimodal treatment of locally
                      advanced HNSCC. It could be used to intensify
                      chemoradiotherapy or as alternative to chemotherapy.},
      keywords     = {chemoradiotherapy (Other) / head and neck cancer (Other) /
                      radiotherapy (Other) / squamous cell carcinoma of head and
                      neck (Other) / tumor treating fields (Other)},
      cin          = {E055 / E221},
      ddc          = {610},
      cid          = {I:(DE-He78)E055-20160331 / I:(DE-He78)E221-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36872620},
      doi          = {10.1002/hed.27298},
      url          = {https://inrepo02.dkfz.de/record/274148},
}