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@ARTICLE{Isbell:274155,
      author       = {L. K. Isbell and C. Tschuch and S. Doostkam and S. Waldeck
                      and G. Andrieux$^*$ and K. Shoumariyeh$^*$ and D. Lenhard
                      and H. E. Schaefer and P. C. Reinacher and I. Bartsch and M.
                      Pantic and J. M. Vinnakota and V. Kakkassery and E. Schorb
                      and F. Scherer$^*$ and A. V. Frey and M. Börries$^*$ and G.
                      Illerhaus and J. Duyster$^*$ and J. Schueler and N. von
                      Bubnoff$^*$},
      title        = {{P}atient-derived xenograft mouse models to investigate
                      tropism to the central nervous system and retina of primary
                      and secondary central nervous system lymphoma.},
      journal      = {Neuropathology $\&$ applied neurobiology},
      volume       = {49},
      number       = {2},
      issn         = {0305-1846},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2023-00461},
      pages        = {e12899},
      year         = {2023},
      note         = {2023 Apr;49(2):e12899},
      abstract     = {How and why lymphoma cells home to the central nervous
                      system and vitreoretinal compartment in primary diffuse
                      large B-cell lymphoma of the central nervous system remain
                      unknown. Our aim was to create an in vivo model to study
                      lymphoma cell tropism to the central nervous system.We
                      established a patient-derived central nervous system
                      lymphoma xenograft mouse model and characterised xenografts
                      derived from 4 primary and 4 secondary central nervous
                      system lymphoma patients using immunohistochemistry, flow
                      cytometry and nucleic acid sequencing technology. In
                      reimplantation experiments, we analysed dissemination
                      patterns of orthotopic and heterotopic xenografts and
                      performed RNA sequencing of different involved organs to
                      detect differences at the transcriptome level.We found that
                      xenografted primary central nervous system lymphoma cells
                      home to the central nervous system and eye after
                      intrasplenic transplantation, mimicking central nervous
                      system and primary vitreoretinal lymphoma pathology,
                      respectively. Transcriptomic analysis revealed distinct
                      signatures for lymphoma cells in the brain in comparison to
                      the spleen as well as a small overlap of commonly regulated
                      genes in both primary and secondary central nervous system
                      lymphoma.This in vivo tumour model preserves key features of
                      primary and secondary central nervous system lymphoma and
                      can be used to explore critical pathways for the central
                      nervous system and retinal tropism with the goal to find new
                      targets for novel therapeutic approaches.},
      keywords     = {CNS tropism (Other) / patient-derived xenograft (Other) /
                      primary and secondary central nervous system lymphoma
                      (Other) / primary vitreoretinal lymphoma (Other)},
      cin          = {FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36879456},
      doi          = {10.1111/nan.12899},
      url          = {https://inrepo02.dkfz.de/record/274155},
}