%0 Journal Article
%A Winkelkotte, Alina
%A Schulze, Almut
%T Palmitate paves the way to lung metastasis.
%J Trends in cancer
%V 9
%N 5
%@ 2405-8033
%C Amsterdam
%I Elsevier
%M DKFZ-2023-00594
%P 376-378 
%D 2023
%Z #EA:A410#LA:A410# / 2023 May;9(5):376-378 / Spotlight
%X New findings by Altea-Manzano et al. demonstrate that primary breast tumours or a high-fat diet induce palmitate secretion by alveolar type 2 (AT2) cells to prepare a premetastatic niche that promotes lung metastasis. Palmitate is utilised by cancer cells via carnitine palmitoyltransferase 1a (CPT1a) and lysine acetyltransferase 2a (KAT2a) to acetylate nuclear factor-κB (NF-κB)/p65. Blocking these enzymes reduced metastasis formation in both lean and high-fat diet mice.
%K NF-kB (Other)
%K breast cancer (Other)
%K lung metastasis (Other)
%K palmitate (Other)
%K premetastatic niche (Other)
%K protein acetylation (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36959035
%R 10.1016/j.trecan.2023.03.001
%U https://inrepo02.dkfz.de/record/274430