Journal Article

DKFZ-2023-00594

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Palmitate paves the way to lung metastasis.

Winkelkotte, A. (First author)DKFZ* ; Schulze, A. (Last author)DKFZ*

2023
Elsevier Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.trecan.2023.03.001

Abstract: New findings by Altea-Manzano et al. demonstrate that primary breast tumours or a high-fat diet induce palmitate secretion by alveolar type 2 (AT2) cells to prepare a premetastatic niche that promotes lung metastasis. Palmitate is utilised by cancer cells via carnitine palmitoyltransferase 1a (CPT1a) and lysine acetyltransferase 2a (KAT2a) to acetylate nuclear factor-κB (NF-κB)/p65. Blocking these enzymes reduced metastasis formation in both lean and high-fat diet mice.

Keyword(s): NF-kB ; breast cancer ; lung metastasis ; palmitate ; premetastatic niche ; protein acetylation

Note: #EA:A410#LA:A410# / 2023 May;9(5):376-378 / Spotlight

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Contributing Institute(s):

1. Metabolismus und Microenvironment (A410)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2023

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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