TY  - JOUR
AU  - Winkelkotte, Alina
AU  - Schulze, Almut
TI  - Palmitate paves the way to lung metastasis.
JO  - Trends in cancer
VL  - 9
IS  - 5
SN  - 2405-8033
CY  - Amsterdam
PB  - Elsevier
M1  - DKFZ-2023-00594
SP  - 376-378 
PY  - 2023
N1  - #EA:A410#LA:A410# / 2023 May;9(5):376-378 / Spotlight
AB  - New findings by Altea-Manzano et al. demonstrate that primary breast tumours or a high-fat diet induce palmitate secretion by alveolar type 2 (AT2) cells to prepare a premetastatic niche that promotes lung metastasis. Palmitate is utilised by cancer cells via carnitine palmitoyltransferase 1a (CPT1a) and lysine acetyltransferase 2a (KAT2a) to acetylate nuclear factor-κB (NF-κB)/p65. Blocking these enzymes reduced metastasis formation in both lean and high-fat diet mice.
KW  - NF-kB (Other)
KW  - breast cancer (Other)
KW  - lung metastasis (Other)
KW  - palmitate (Other)
KW  - premetastatic niche (Other)
KW  - protein acetylation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36959035
DO  - DOI:10.1016/j.trecan.2023.03.001
UR  - https://inrepo02.dkfz.de/record/274430
ER  -