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000274476 0247_ $$2doi$$a10.1016/j.dld.2023.02.023
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000274476 0247_ $$2ISSN$$a1878-3562
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000274476 037__ $$aDKFZ-2023-00621
000274476 041__ $$aEnglish
000274476 082__ $$a610
000274476 1001_ $$aNodari, Ylenia$$b0
000274476 245__ $$aGenetic and non-genetic risk factors for early-onset pancreatic cancer.
000274476 260__ $$a[Erscheinungsort nicht ermittelbar]$$bSaunders$$c2023
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000274476 500__ $$a2023 Oct;55(10):1417-1425
000274476 520__ $$aEarly-onset pancreatic cancer (EOPC) represents 5-10% of all pancreatic ductal adenocarcinoma (PDAC) cases, and the etiology of this form is poorly understood. It is not clear if established PDAC risk factors have the same relevance for younger patients. This study aims to identify genetic and non-genetic risk factors specific to EOPC.A genome-wide association study was performed, analysing 912 EOPC cases and 10 222 controls, divided into discovery and replication phases. Furthermore, the associations between a polygenic risk score (PRS), smoking, alcohol consumption, type 2 diabetes and PDAC risk were also assessed.Six novel SNPs were associated with EOPC risk in the discovery phase, but not in the replication phase. The PRS, smoking, and diabetes affected EOPC risk. The OR comparing current smokers to never-smokers was 2.92 (95% CI 1.69-5.04, P = 1.44 × 10-4). For diabetes, the corresponding OR was 14.95 (95% CI 3.41-65.50, P = 3.58 × 10-4).In conclusion, we did not identify novel genetic variants associated specifically with EOPC, and we found that established PDAC risk variants do not have a strong age-dependent effect. Furthermore, we add to the evidence pointing to the role of smoking and diabetes in EOPC.
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000274476 650_7 $$2Other$$aEarly onset
000274476 650_7 $$2Other$$aGWAS
000274476 650_7 $$2Other$$aPancreatic cancer
000274476 650_7 $$2Other$$aRisk factor
000274476 7001_ $$aGentiluomo, Manuel$$b1
000274476 7001_ $$aMohelnikova-Duchonova, Beatrice$$b2
000274476 7001_ $$aKreivenaite, Edita$$b3
000274476 7001_ $$aMilanetto, Anna Caterina$$b4
000274476 7001_ $$aSkieceviciene, Jurgita$$b5
000274476 7001_ $$aLandi, Stefano$$b6
000274476 7001_ $$aLawlor, Rita T$$b7
000274476 7001_ $$aPetrone, Maria Chiara$$b8
000274476 7001_ $$aArcidiacono, Paolo Giorgio$$b9
000274476 7001_ $$aLovecek, Martin$$b10
000274476 7001_ $$aGazouli, Maria$$b11
000274476 7001_ $$aBijlsma, Maarten F$$b12
000274476 7001_ $$aMorelli, Luca$$b13
000274476 7001_ $$aKiudelis, Vytautas$$b14
000274476 7001_ $$aTacelli, Matteo$$b15
000274476 7001_ $$aZanette, Dalila Lucíola$$b16
000274476 7001_ $$aSoucek, Pavel$$b17
000274476 7001_ $$aUzunoglu, Faik$$b18
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000274476 7001_ $$aIzbicki, Jakob$$b20
000274476 7001_ $$aBoggi, Ugo$$b21
000274476 7001_ $$aPezzilli, Raffaele$$b22
000274476 7001_ $$aMambrini, Andrea$$b23
000274476 7001_ $$aPasquali, Claudio$$b24
000274476 7001_ $$avan Laarhoven, Hanneke W$$b25
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000274476 7001_ $$aCavestro, Giulia Martina$$b27
000274476 7001_ $$aSperti, Cosimo$$b28
000274476 7001_ $$aLoos, Martin$$b29
000274476 7001_ $$aLatiano, Anna$$b30
000274476 7001_ $$aErőss, Bálint$$b31
000274476 7001_ $$aOliverius, Martin$$b32
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000274476 7001_ $$aBasso, Daniela$$b34
000274476 7001_ $$aNeoptolemos, John P$$b35
000274476 7001_ $$aAoki, Mateus Nóbrega$$b36
000274476 7001_ $$aGreenhalf, William$$b37
000274476 7001_ $$aVodicka, Pavel$$b38
000274476 7001_ $$aArchibugi, Livia$$b39
000274476 7001_ $$aVanella, Giuseppe$$b40
000274476 7001_ $$aLucchesi, Maurizio$$b41
000274476 7001_ $$aTalar-Wojnarowska, Renata$$b42
000274476 7001_ $$aJamroziak, Krzysztof$$b43
000274476 7001_ $$aSaeedi, Mohammed Al$$b44
000274476 7001_ $$avan Eijck, Casper H J$$b45
000274476 7001_ $$aKupcinskas, Juozas$$b46
000274476 7001_ $$aHussein, Tamás$$b47
000274476 7001_ $$aPuzzono, Marta$$b48
000274476 7001_ $$aBunduc, Stefania$$b49
000274476 7001_ $$aGötz, Mara$$b50
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000274476 7001_ $$aSzentesi, Andrea$$b52
000274476 7001_ $$aTavano, Francesca$$b53
000274476 7001_ $$aMoz, Stefania$$b54
000274476 7001_ $$aHegyi, Péter$$b55
000274476 7001_ $$aLuchini, Claudio$$b56
000274476 7001_ $$aCapurso, Gabriele$$b57
000274476 7001_ $$aPerri, Francesco$$b58
000274476 7001_ $$aErmini, Stefano$$b59
000274476 7001_ $$aTheodoropoulos, George$$b60
000274476 7001_ $$aCapretti, Giovanni$$b61
000274476 7001_ $$aPalmieri, Orazio$$b62
000274476 7001_ $$aGinocchi, Laura$$b63
000274476 7001_ $$aFurbetta, Niccolò$$b64
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000274476 7001_ $$aCampa, Daniele$$b66
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