Journal Article

DKFZ-2023-00621

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genetic and non-genetic risk factors for early-onset pancreatic cancer.

Nodari, Y. ; Gentiluomo, M. ; Mohelnikova-Duchonova, B. ; Kreivenaite, E. ; Milanetto, A. C. ; Skieceviciene, J. ; Landi, S. ; Lawlor, R. T. ; Petrone, M. C. ; Arcidiacono, P. G. ; Lovecek, M. ; Gazouli, M. ; Bijlsma, M. F. ; Morelli, L. ; Kiudelis, V. ; Tacelli, M. ; Zanette, D. L. ; Soucek, P. ; Uzunoglu, F. ; Kaaks, R.DKFZ* ; Izbicki, J. ; Boggi, U. ; Pezzilli, R. ; Mambrini, A. ; Pasquali, C. ; van Laarhoven, H. W. ; Katzke, V.DKFZ* ; Cavestro, G. M. ; Sperti, C. ; Loos, M. ; Latiano, A. ; Erőss, B. ; Oliverius, M. ; Johnson, T.DKFZ* ; Basso, D. ; Neoptolemos, J. P. ; Aoki, M. N. ; Greenhalf, W. ; Vodicka, P. ; Archibugi, L. ; Vanella, G. ; Lucchesi, M. ; Talar-Wojnarowska, R. ; Jamroziak, K. ; Saeedi, M. A. ; van Eijck, C. H. J. ; Kupcinskas, J. ; Hussein, T. ; Puzzono, M. ; Bunduc, S. ; Götz, M. ; Carrara, S. ; Szentesi, A. ; Tavano, F. ; Moz, S. ; Hegyi, P. ; Luchini, C. ; Capurso, G. ; Perri, F. ; Ermini, S. ; Theodoropoulos, G. ; Capretti, G. ; Palmieri, O. ; Ginocchi, L. ; Furbetta, N. ; Canzian, F.DKFZ* ; Campa, D.

2023
Saunders [Erscheinungsort nicht ermittelbar]

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Please use a persistent id in citations: doi:10.1016/j.dld.2023.02.023

Abstract: Early-onset pancreatic cancer (EOPC) represents 5-10% of all pancreatic ductal adenocarcinoma (PDAC) cases, and the etiology of this form is poorly understood. It is not clear if established PDAC risk factors have the same relevance for younger patients. This study aims to identify genetic and non-genetic risk factors specific to EOPC.A genome-wide association study was performed, analysing 912 EOPC cases and 10 222 controls, divided into discovery and replication phases. Furthermore, the associations between a polygenic risk score (PRS), smoking, alcohol consumption, type 2 diabetes and PDAC risk were also assessed.Six novel SNPs were associated with EOPC risk in the discovery phase, but not in the replication phase. The PRS, smoking, and diabetes affected EOPC risk. The OR comparing current smokers to never-smokers was 2.92 (95% CI 1.69-5.04, P = 1.44 × 10-4). For diabetes, the corresponding OR was 14.95 (95% CI 3.41-65.50, P = 3.58 × 10-4).In conclusion, we did not identify novel genetic variants associated specifically with EOPC, and we found that established PDAC risk variants do not have a strong age-dependent effect. Furthermore, we add to the evidence pointing to the role of smoking and diabetes in EOPC.

Keyword(s): Early onset ; GWAS ; Pancreatic cancer ; Risk factor

Note: 2023 Oct;55(10):1417-1425

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)
2. C055 Genomische Epidemiologie (C055)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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