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@ARTICLE{Nodari:274476,
      author       = {Y. Nodari and M. Gentiluomo and B. Mohelnikova-Duchonova
                      and E. Kreivenaite and A. C. Milanetto and J. Skieceviciene
                      and S. Landi and R. T. Lawlor and M. C. Petrone and P. G.
                      Arcidiacono and M. Lovecek and M. Gazouli and M. F. Bijlsma
                      and L. Morelli and V. Kiudelis and M. Tacelli and D. L.
                      Zanette and P. Soucek and F. Uzunoglu and R. Kaaks$^*$ and
                      J. Izbicki and U. Boggi and R. Pezzilli and A. Mambrini and
                      C. Pasquali and H. W. van Laarhoven and V. Katzke$^*$ and G.
                      M. Cavestro and C. Sperti and M. Loos and A. Latiano and B.
                      Erőss and M. Oliverius and T. Johnson$^*$ and D. Basso and
                      J. P. Neoptolemos and M. N. Aoki and W. Greenhalf and P.
                      Vodicka and L. Archibugi and G. Vanella and M. Lucchesi and
                      R. Talar-Wojnarowska and K. Jamroziak and M. A. Saeedi and
                      C. H. J. van Eijck and J. Kupcinskas and T. Hussein and M.
                      Puzzono and S. Bunduc and M. Götz and S. Carrara and A.
                      Szentesi and F. Tavano and S. Moz and P. Hegyi and C.
                      Luchini and G. Capurso and F. Perri and S. Ermini and G.
                      Theodoropoulos and G. Capretti and O. Palmieri and L.
                      Ginocchi and N. Furbetta and F. Canzian$^*$ and D. Campa},
      title        = {{G}enetic and non-genetic risk factors for early-onset
                      pancreatic cancer.},
      journal      = {Digestive and liver disease},
      volume       = {55},
      number       = {10},
      issn         = {1590-8658},
      address      = {[Erscheinungsort nicht ermittelbar]},
      publisher    = {Saunders},
      reportid     = {DKFZ-2023-00621},
      pages        = {1417-1425},
      year         = {2023},
      note         = {2023 Oct;55(10):1417-1425},
      abstract     = {Early-onset pancreatic cancer (EOPC) represents $5-10\%$ of
                      all pancreatic ductal adenocarcinoma (PDAC) cases, and the
                      etiology of this form is poorly understood. It is not clear
                      if established PDAC risk factors have the same relevance for
                      younger patients. This study aims to identify genetic and
                      non-genetic risk factors specific to EOPC.A genome-wide
                      association study was performed, analysing 912 EOPC cases
                      and 10 222 controls, divided into discovery and replication
                      phases. Furthermore, the associations between a polygenic
                      risk score (PRS), smoking, alcohol consumption, type 2
                      diabetes and PDAC risk were also assessed.Six novel SNPs
                      were associated with EOPC risk in the discovery phase, but
                      not in the replication phase. The PRS, smoking, and diabetes
                      affected EOPC risk. The OR comparing current smokers to
                      never-smokers was 2.92 $(95\%$ CI 1.69-5.04, P = 1.44 ×
                      10-4). For diabetes, the corresponding OR was 14.95 $(95\%$
                      CI 3.41-65.50, P = 3.58 × 10-4).In conclusion, we did not
                      identify novel genetic variants associated specifically with
                      EOPC, and we found that established PDAC risk variants do
                      not have a strong age-dependent effect. Furthermore, we add
                      to the evidence pointing to the role of smoking and diabetes
                      in EOPC.},
      keywords     = {Early onset (Other) / GWAS (Other) / Pancreatic cancer
                      (Other) / Risk factor (Other)},
      cin          = {C020 / C055},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C055-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36973108},
      doi          = {10.1016/j.dld.2023.02.023},
      url          = {https://inrepo02.dkfz.de/record/274476},
}