Journal Article

DKFZ-2023-00625

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Persisting Deficits in Health-Related Quality of Life of Colorectal Cancer Survivors 14-24 Years Post-Diagnosis: A Population-Based Study.

Thong, M. (First author)DKFZ* ; Doege, D.DKFZ* ; Weißer, L.DKFZ* ; Koch-Gallenkamp, L.DKFZ* ; Jansen, L.DKFZ* ; Bertram, H. ; Eberle, A. ; Holleczek, B. ; Nennecke, A. ; Waldmann, A. ; Zeissig, S. R. ; Brenner, H.DKFZ* ; Arndt, V. (Last author)DKFZ*

2023
Multimed Toronto, Ontario

This record in other databases:  

Please use a persistent id in citations: doi:10.3390/curroncol30030257

Abstract: (1) Background: The health-related quality of life (HRQOL) of colorectal cancer (CRC) survivors >10 years post-diagnosis is understudied. We aimed to compare the HRQOL of CRC survivors 14-24 years post-diagnosis to that of age- and sex-matched non-cancer controls, stratified by demographic and clinical factors. (2) Methods: We used data from 506 long-term CRC survivors and 1489 controls recruited from German population-based multi-regional studies. HRQOL was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Core-30 (EORTC QLQ-C30) questionnaire. We estimated differences in the HRQOL of CRC survivors and controls with multiple regression, adjusted for age at survey, sex, and education, where appropriate. (3) Results: CRC survivors reported poorer social functioning but better health status/QOL than controls. CRC survivors, in general, had higher levels of symptom burden, and in particular diarrhea and constipation, regardless of demographic or clinical factors. In stratified analyses, HRQOL differed by age, sex, cancer type, and having a permanent stoma. (4) Conclusions: Although CRC survivors may have a comparable health status/QOL to controls 14-24 years after diagnosis, they still live with persistent bowel dysfunction that can negatively impact aspects of functioning. Healthcare providers should provide timely and adapted follow-up care to ameliorate potential long-term suffering.

Keyword(s): colorectal cancer ; health-related quality of life ; long-term survivors ; non-cancer controls ; population-based

Note: #EA:C071#LA:C071#

---

Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)
2. C071 Cancer Survivorship (C071)
3. Präventive Onkologie (C120)
4. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

---

Database coverage:
; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---