Journal Article

DKFZ-2023-00700

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Reg3α concentrations at day of allogeneic stem cell transplantation predict outcome and correlate with early antibiotic use.

Weber, D. ; Weber, M. ; Meedt, E. ; Ghimire, S. ; Wolff, D. ; Edinger, M. ; Poeck, H. ; Hiergeist, A. ; Gessner, A. ; Ayuk, F. ; Roesler, W. ; Wölfl, M. ; Kraus, S. ; Zeiser, R. ; Bertrand, H. ; Bader, P. ; Ullrich, E.DKFZ* ; Eder, M. ; Gleich, S. ; Young, R. ; Herr, W. ; Levine, J. E. ; Ferrara, J. L. M. ; Holler, E.

2023
American Society of Hematology Washington, DC

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Please use a persistent id in citations: doi:10.1182/bloodadvances.2022008480

Abstract: Intestinal microbiome diversity plays an important role in the pathophysiology of acute gastrointestinal (GI) graft-versus-host disease (GVHD) and influences the outcome of patients after allogeneic stem cell transplantation (ASCT). We analyzed clinical data and blood samples taken preconditioning and on the day of ASCT from 587 patients from 7 German centers of the Mount Sinai Acute GVHD International Consortium, dividing them into single-center test (n = 371) and multicenter validation (n = 216) cohorts. Regenerating islet-derived 3α (Reg3α) serum concentration of day 0 correlated with clinical data as well as urinary 3-indoxylsulfate (3-IS) and Clostridiales group XIVa, indicators of intestinal microbiome diversity. High Reg3α concentration at day 0 of ASCT was associated with higher 1-year transplant-related mortality (TRM) in both cohorts (P < .001). Cox regression analysis revealed high Reg3α at day 0 as an independent prognostic factor for 1-year TRM. Multivariable analysis showed an independent correlation of high Reg3α concentrations at day 0 with early systemic antibiotic (AB) treatment. Urinary 3-IS (P = .04) and Clostridiales group XIVa (P = .004) were lower in patients with high vs those with low day 0 Reg3α concentrations. In contrast, Reg3α concentrations before conditioning therapy correlated neither with TRM nor disease or treatment-related parameters. Reg3α, a known biomarker of acute GI GVHD correlates with intestinal dysbiosis, induced by early AB treatment in the period of pretransplant conditioning. Serum concentrations of Reg3α measured on the day of graft infusion are predictive of the risk for TRM of ASCT recipients.

Keyword(s): Humans (MeSH) ; Anti-Bacterial Agents (MeSH) ; Biomarkers (MeSH) ; Graft vs Host Disease: diagnosis (MeSH) ; Graft vs Host Disease: etiology (MeSH) ; Hematopoietic Stem Cell Transplantation: adverse effects (MeSH) ; Transplantation, Homologous (MeSH) ; Anti-Bacterial Agents ; Biomarkers ; REG3A protein, human

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Contributing Institute(s):

1. DKTK FM zentral (FM01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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