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@ARTICLE{Stgbauer:275372,
      author       = {F. Stögbauer and S. Beck and I. Ourailidis and J. Hess$^*$
                      and C. Poremba and M. Lauterbach and B. Wollenberg and A. M.
                      S. Buchberger and M. Jesinghaus and P. Schirmacher$^*$ and
                      A. Stenzinger$^*$ and W. Weichert$^*$ and M. Boxberg$^*$ and
                      J. Budczies$^*$},
      title        = {{T}umour budding-based grading as independent prognostic
                      biomarker in {HPV}-positive and {HPV}-negative head and neck
                      cancer.},
      journal      = {British journal of cancer},
      volume       = {128},
      number       = {12},
      issn         = {0007-0920},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2023-00738},
      pages        = {2295-2306},
      year         = {2023},
      note         = {2023 Jun;128(12):2295-2306},
      abstract     = {The prognostic significance of tumour budding (TB) and
                      minimal cell nest size (MCNS) was shown in human
                      papillomavirus (HPV)-negative head and neck squamous cell
                      carcinomas (HNSCC). However, the optimisation of cutpoints,
                      the prognostic impact in HPV-positive HNSCC, and the
                      comparison with other histopathological grading systems are
                      insufficiently investigated.TB and MCNS were analysed
                      digitally in 1 and 10 high-power fields (HPF) of 331
                      HPV-positive and HPV-negative cases from TCGA. Optimising
                      the cutpoints a new cellular dissociation grading (CDG)
                      system was defined and compared to the WHO grading and the
                      Brandwein-Gensler (BG) risk model.The two-tiered CDG system
                      based solely on TB yielded optimal prognostic stratification
                      with shortened overall survival for CDG-high cases. Optimal
                      cut-offs were two buds (1 HPF) and six buds (10 HPF),
                      respectively. Analysing MCNS did not add prognostic
                      significance to quantifying TB. CDG was a significant
                      prognostic marker in HPV-negative and HPV-positive tumours
                      and prognostically superior to the WHO and BG systems. High
                      CDG was associated with clinically occult lymph-node
                      metastases.The most comprehensive study of TB in HNSCC so
                      far confirmed its prognostic impact in HPV-negative tumours
                      and for the first time in HPV-positive tumours. Further
                      studies are warranted to evaluate its applicability for
                      therapy guidance in HNSCC.},
      cin          = {E221 / HD01 / MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)E221-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)MU01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37045906},
      doi          = {10.1038/s41416-023-02240-y},
      url          = {https://inrepo02.dkfz.de/record/275372},
}