Journal Article

DKFZ-2023-00738

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Tumour budding-based grading as independent prognostic biomarker in HPV-positive and HPV-negative head and neck cancer.

Stögbauer, F. ; Beck, S. ; Ourailidis, I. ; Hess, J.DKFZ* ; Poremba, C. ; Lauterbach, M. ; Wollenberg, B. ; Buchberger, A. M. S. ; Jesinghaus, M. ; Schirmacher, P.DKFZ* ; Stenzinger, A.DKFZ* ; Weichert, W.DKFZ* ; Boxberg, M.DKFZ* ; Budczies, J.DKFZ*

2023
Nature Publ. Group Edinburgh

Abstract: The prognostic significance of tumour budding (TB) and minimal cell nest size (MCNS) was shown in human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC). However, the optimisation of cutpoints, the prognostic impact in HPV-positive HNSCC, and the comparison with other histopathological grading systems are insufficiently investigated.TB and MCNS were analysed digitally in 1 and 10 high-power fields (HPF) of 331 HPV-positive and HPV-negative cases from TCGA. Optimising the cutpoints a new cellular dissociation grading (CDG) system was defined and compared to the WHO grading and the Brandwein-Gensler (BG) risk model.The two-tiered CDG system based solely on TB yielded optimal prognostic stratification with shortened overall survival for CDG-high cases. Optimal cut-offs were two buds (1 HPF) and six buds (10 HPF), respectively. Analysing MCNS did not add prognostic significance to quantifying TB. CDG was a significant prognostic marker in HPV-negative and HPV-positive tumours and prognostically superior to the WHO and BG systems. High CDG was associated with clinically occult lymph-node metastases.The most comprehensive study of TB in HNSCC so far confirmed its prognostic impact in HPV-negative tumours and for the first time in HPV-positive tumours. Further studies are warranted to evaluate its applicability for therapy guidance in HNSCC.

Note: 2023 Jun;128(12):2295-2306

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Contributing Institute(s):

1. Molekulare Grundlagen von HNO-Tumoren (E221)
2. DKTK HD zentral (HD01)
3. DKTK MU LMU zentral (MU01)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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