TY  - JOUR
AU  - Winkler, Frank
AU  - Venkatesh, Humsa S.
AU  - Amit, Moran
AU  - Batchelor, Tracy
AU  - Demir, Ihsan Ekin
AU  - Deneen, Benjamin
AU  - Gutmann, David H.
AU  - Hervey-Jumper, Shawn
AU  - Kuner, Thomas
AU  - Mabbott, Donald
AU  - Platten, Michael
AU  - Rolls, Asya
AU  - Sloan, Erica K.
AU  - Wang, Timothy C.
AU  - Wick, Wolfgang
AU  - Venkataramani, Varun
AU  - Monje, Michelle
TI  - Cancer neuroscience: State of the field, emerging directions
JO  - Cell
VL  - 186
IS  - 8
SN  - 0092-8674
CY  - New York, NY
PB  - Elsevier
M1  - DKFZ-2023-00757
SP  - 1689 - 1707
PY  - 2023
N1  - #EA:B320#LA:B320#
AB  - The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, and promoting plasticity throughout life, the nervous system plays parallel roles in the regulation of cancers. Foundational discoveries have elucidated direct paracrine and electrochemical communication between neurons and cancer cells, as well as indirect interactions through neural effects on the immune system and stromal cells in the tumor microenvironment in a wide range of malignancies. Nervous system-cancer interactions can regulate oncogenesis, growth, invasion and metastatic spread, treatment resistance, stimulation of tumor-promoting inflammation, and impairment of anti-cancer immunity. Progress in cancer neuroscience may create an important new pillar of cancer therapy.
LB  - PUB:(DE-HGF)16
C6  - pmid:37059069
DO  - DOI:10.1016/j.cell.2023.02.002
UR  - https://inrepo02.dkfz.de/record/275434
ER  -