Journal Article (Review Article)

DKFZ-2023-00757

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Winkler, F. (First author)DKFZ* ; Venkatesh, H. S. ; Amit, M. ; Batchelor, T. ; Demir, I. E. ; Deneen, B. ; Gutmann, D. H. ; Hervey-Jumper, S. ; Kuner, T. ; Mabbott, D. ; Platten, M. ; Rolls, A. ; Sloan, E. K. ; Wang, T. C. ; Wick, W.DKFZ* ; Venkataramani, V. (Last author)DKFZ* ; Monje, M.

2023
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.cell.2023.02.002

Abstract: The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, and promoting plasticity throughout life, the nervous system plays parallel roles in the regulation of cancers. Foundational discoveries have elucidated direct paracrine and electrochemical communication between neurons and cancer cells, as well as indirect interactions through neural effects on the immune system and stromal cells in the tumor microenvironment in a wide range of malignancies. Nervous system-cancer interactions can regulate oncogenesis, growth, invasion and metastatic spread, treatment resistance, stimulation of tumor-promoting inflammation, and impairment of anti-cancer immunity. Progress in cancer neuroscience may create an important new pillar of cancer therapy.

Note: #EA:B320#LA:B320#

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Contributing Institute(s):

1. KKE Neuroonkologie (B320)
2. DKTK HD zentral (HD01)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 60 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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