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@ARTICLE{Winkler:275434,
author = {F. Winkler$^*$ and H. S. Venkatesh and M. Amit and T.
Batchelor and I. E. Demir and B. Deneen and D. H. Gutmann
and S. Hervey-Jumper and T. Kuner and D. Mabbott and M.
Platten and A. Rolls and E. K. Sloan and T. C. Wang and W.
Wick$^*$ and V. Venkataramani$^*$ and M. Monje},
title = {{C}ancer neuroscience: {S}tate of the field, emerging
directions},
journal = {Cell},
volume = {186},
number = {8},
issn = {0092-8674},
address = {New York, NY},
publisher = {Elsevier},
reportid = {DKFZ-2023-00757},
pages = {1689 - 1707},
year = {2023},
note = {#EA:B320#LA:B320#},
abstract = {The nervous system governs both ontogeny and oncology.
Regulating organogenesis during development, maintaining
homeostasis, and promoting plasticity throughout life, the
nervous system plays parallel roles in the regulation of
cancers. Foundational discoveries have elucidated direct
paracrine and electrochemical communication between neurons
and cancer cells, as well as indirect interactions through
neural effects on the immune system and stromal cells in the
tumor microenvironment in a wide range of malignancies.
Nervous system-cancer interactions can regulate oncogenesis,
growth, invasion and metastatic spread, treatment
resistance, stimulation of tumor-promoting inflammation, and
impairment of anti-cancer immunity. Progress in cancer
neuroscience may create an important new pillar of cancer
therapy.},
subtyp = {Review Article},
cin = {B320 / HD01},
ddc = {610},
cid = {I:(DE-He78)B320-20160331 / I:(DE-He78)HD01-20160331},
pnm = {312 - Funktionelle und strukturelle Genomforschung
(POF4-312)},
pid = {G:(DE-HGF)POF4-312},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:37059069},
doi = {10.1016/j.cell.2023.02.002},
url = {https://inrepo02.dkfz.de/record/275434},
}