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@ARTICLE{Marra:275752,
      author       = {G. Marra and G. J. L. H. van Leenders and F. Zattoni and C.
                      Kesch$^*$ and P. Rajwa and P. Cornford and T. van der Kwast
                      and R. C. N. van den Bergh and E. Briers and T. Van den
                      Broeck and G. De Meerleer and M. De Santis and D. Eberli and
                      A. Farolfi and S. Gillessen and N. Grivas and J. P. Grummet
                      and A. M. Henry and M. Lardas and M. Lieuw and E. Linares
                      Espinós and M. D. Mason and S. O'Hanlon and I. M. van Oort
                      and D. E. Oprea-Lager and G. Ploussard and O. Rouvière and
                      I. G. Schoots and J. Stranne and D. Tilki and T. Wiegel and
                      P. M. Willemse and N. Mottet and G. Gandaglia},
      collaboration = {t. E. G. P. o. P. C. European Association of Urology Young
                      Academic Urologists Prostate Cancer Working Group},
      title        = {{I}mpact of {E}pithelial {H}istological {T}ypes,
                      {S}ubtypes, and {G}rowth {P}atterns on {O}ncological
                      {O}utcomes for {P}atients with {N}onmetastatic {P}rostate
                      {C}ancer {T}reated with {C}urative {I}ntent: {A}
                      {S}ystematic {R}eview.},
      journal      = {European urology},
      volume       = {84},
      number       = {1},
      issn         = {0302-2838},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2023-00851},
      pages        = {65-85},
      year         = {2023},
      note         = {2023 Jul;84(1):65-85},
      abstract     = {The optimal management for men with prostate cancer (PCa)
                      with unconventional histology (UH) is unknown. The outcome
                      for these cancers might be worse than for conventional PCa
                      and so different approaches may be needed.To compare
                      oncological outcomes for conventional and UH PCa in men with
                      localized disease treated with curative intent.A systematic
                      review adhering to the Referred Reporting Items for
                      Systematic Reviews and Meta-Analyses was prospectively
                      registered on PROSPERO (CRD42022296013) was performed in
                      July 2021.We screened 3651 manuscripts and identified 46
                      eligible studies (reporting on 1 871 814 men with
                      conventional PCa and 6929 men with 10 different PCa UHs).
                      Extraprostatic extension and lymph node metastases, but not
                      positive margin rates, were more common with UH PCa than
                      with conventional tumors. PCa cases with cribriform pattern,
                      intraductal carcinoma, or ductal adenocarcinoma had higher
                      rates of biochemical recurrence and metastases after radical
                      prostatectomy than for conventional PCa cases. Lower
                      cancer-specific survival rates were observed for mixed
                      cribriform/intraductal and cribriform PCa. By contrast,
                      pathological findings and oncological outcomes for mucinous
                      and prostatic intraepithelial neoplasia (PIN)-like PCa were
                      similar to those for conventional PCa. Limitations of this
                      review include low-quality studies, a risk of reporting
                      bias, and a scarcity of studies that included
                      radiotherapy.Intraductal, cribriform, and ductal UHs may
                      have worse oncological outcomes than for conventional and
                      mucinous or PIN-like PCa. Alternative treatment approaches
                      need to be evaluated in men with these cancers.We reviewed
                      the literature to explore whether prostate cancers with
                      unconventional growth patterns behave differently to
                      conventional prostate cancers. We found that some
                      unconventional growth patterns have worse outcomes, so we
                      need to investigate if they need different treatments.
                      Urologists should be aware of these growth patterns and
                      their clinical impact.},
      subtyp        = {Review Article},
      keywords     = {Curative-intent treatment (Other) / Nonmetastatic (Other) /
                      Prostate cancer (Other) / Unconventional histology (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37117107},
      doi          = {10.1016/j.eururo.2023.03.014},
      url          = {https://inrepo02.dkfz.de/record/275752},
}