Journal Article (Review Article)

DKFZ-2023-00851

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Impact of Epithelial Histological Types, Subtypes, and Growth Patterns on Oncological Outcomes for Patients with Nonmetastatic Prostate Cancer Treated with Curative Intent: A Systematic Review.

Marra, G. ; van Leenders, G. J. L. H. ; Zattoni, F. ; Kesch, C.DKFZ* ; Rajwa, P. ; Cornford, P. ; van der Kwast, T. ; van den Bergh, R. C. N. ; Briers, E. ; Van den Broeck, T. ; De Meerleer, G. ; De Santis, M. ; Eberli, D. ; Farolfi, A. ; Gillessen, S. ; Grivas, N. ; Grummet, J. P. ; Henry, A. M. ; Lardas, M. ; Lieuw, M. ; Linares Espinós, E. ; Mason, M. D. ; O'Hanlon, S. ; van Oort, I. M. ; Oprea-Lager, D. E. ; Ploussard, G. ; Rouvière, O. ; Schoots, I. G. ; Stranne, J. ; Tilki, D. ; Wiegel, T. ; Willemse, P. M. ; Mottet, N. ; Gandaglia, G. ; European Association of Urology Young Academic Urologists Prostate Cancer Working Group, t. E. G. P. o. P. C. (Collaboration Author)

2023
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.eururo.2023.03.014

Abstract: The optimal management for men with prostate cancer (PCa) with unconventional histology (UH) is unknown. The outcome for these cancers might be worse than for conventional PCa and so different approaches may be needed.To compare oncological outcomes for conventional and UH PCa in men with localized disease treated with curative intent.A systematic review adhering to the Referred Reporting Items for Systematic Reviews and Meta-Analyses was prospectively registered on PROSPERO (CRD42022296013) was performed in July 2021.We screened 3651 manuscripts and identified 46 eligible studies (reporting on 1 871 814 men with conventional PCa and 6929 men with 10 different PCa UHs). Extraprostatic extension and lymph node metastases, but not positive margin rates, were more common with UH PCa than with conventional tumors. PCa cases with cribriform pattern, intraductal carcinoma, or ductal adenocarcinoma had higher rates of biochemical recurrence and metastases after radical prostatectomy than for conventional PCa cases. Lower cancer-specific survival rates were observed for mixed cribriform/intraductal and cribriform PCa. By contrast, pathological findings and oncological outcomes for mucinous and prostatic intraepithelial neoplasia (PIN)-like PCa were similar to those for conventional PCa. Limitations of this review include low-quality studies, a risk of reporting bias, and a scarcity of studies that included radiotherapy.Intraductal, cribriform, and ductal UHs may have worse oncological outcomes than for conventional and mucinous or PIN-like PCa. Alternative treatment approaches need to be evaluated in men with these cancers.We reviewed the literature to explore whether prostate cancers with unconventional growth patterns behave differently to conventional prostate cancers. We found that some unconventional growth patterns have worse outcomes, so we need to investigate if they need different treatments. Urologists should be aware of these growth patterns and their clinical impact.

Keyword(s): Curative-intent treatment ; Nonmetastatic ; Prostate cancer ; Unconventional histology

Note: 2023 Jul;84(1):65-85

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Essen/Düsseldorf (ED01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 20 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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