TY  - JOUR
AU  - Harter, Patrick
AU  - Weber, Katharina
AU  - Ronellenfitsch, Michael W
TI  - Histological and molecular characteristics of tumours of the peripheral nervous system. [Histologische und molekularpathologische Besonderheiten von Tumoren des peripheren Nervensystems].
JO  - Die Pathologie
VL  - 44
IS  - 3
SN  - 2731-7188
CY  - [Berlin]
PB  - Springer Medizin Verlag GmbH
M1  - DKFZ-2023-00853
SP  - 197-208
PY  - 2023
N1  - 2023 May;44(3):197-208
AB  - Tumours of the peripheral nervous system occur sporadically in adults and except for a minority of entities, these tumours are usually benign. The most common are nerve sheath tumours. Because these tumours grow in direct proximity or even invade peripheral nerve bundles, they can lead to severe pain and motion deficits. From the neurosurgical perspective these tumours are technically challenging, and especially for tumours with an invasive growth pattern complete resection may not be possible. Peripheral nervous system tumours that are associated with tumour syndromes such as neurofibromatosis type 1 and 2 or schwannomatosis are a particular clinical challenge. The goal of the current article is to present histological and molecular characteristics of peripheral nervous system tumours. Furthermore, future targeted therapy strategies are presented.
KW  - Neoplastic syndromes, hereditary (Other)
KW  - Nerve sheath neoplasms (Other)
KW  - Neurofibromatosis, type 1 (Other)
KW  - Neuropathology (Other)
KW  - Schwannoma (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37115287
DO  - DOI:10.1007/s00292-023-01198-1
UR  - https://inrepo02.dkfz.de/record/275754
ER  -