Journal Article

DKFZ-2023-00853

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Histological and molecular characteristics of tumours of the peripheral nervous system. [Histologische und molekularpathologische Besonderheiten von Tumoren des peripheren Nervensystems].

Harter, P.DKFZ* ; Weber, K.DKFZ* ; Ronellenfitsch, M. W.DKFZ*

2023
Springer Medizin Verlag GmbH [Berlin]

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Please use a persistent id in citations: doi:10.1007/s00292-023-01198-1

Abstract: Tumours of the peripheral nervous system occur sporadically in adults and except for a minority of entities, these tumours are usually benign. The most common are nerve sheath tumours. Because these tumours grow in direct proximity or even invade peripheral nerve bundles, they can lead to severe pain and motion deficits. From the neurosurgical perspective these tumours are technically challenging, and especially for tumours with an invasive growth pattern complete resection may not be possible. Peripheral nervous system tumours that are associated with tumour syndromes such as neurofibromatosis type 1 and 2 or schwannomatosis are a particular clinical challenge. The goal of the current article is to present histological and molecular characteristics of peripheral nervous system tumours. Furthermore, future targeted therapy strategies are presented.

Keyword(s): Neoplastic syndromes, hereditary ; Nerve sheath neoplasms ; Neurofibromatosis, type 1 ; Neuropathology ; Schwannoma

Note: 2023 May;44(3):197-208

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Contributing Institute(s):

1. DKTK MU LMU zentral (MU01)
2. DKTK FM zentral (FM01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; DEAL Springer ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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