Journal Article

DKFZ-2023-00884

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The first PET glimpse of a proton FLASH beam.

Abouzahr, F. ; Cesar, J. P. ; Crespo, P. ; Gajda, M. J. ; Hu, Z. ; Kaye, W. ; Klein, K. ; Kuo, A. ; Majewski, S. ; Mawlawi, O. R. ; Morozov, A. ; Ojha, A. ; Poenisch, F. ; Polf, J. C. ; Proga, M. ; Sahoo, N. ; Seco, J.DKFZ* ; Takaoka, T. ; Tavernier, S. ; Titt, U. ; Wang, X. ; Zhu, X. R. ; Lang, K.

2023
IOP Publ. Bristol

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Please use a persistent id in citations: doi:10.1088/1361-6560/acd29e

Abstract: We demonstrate the first ever recorded PET imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD~Anderson Cancer Center. Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a~cylindrical PMMA phantom irradiated by a FLASH proton beam. The proton beam had a kinetic energy of 75.8\,MeV and an intensity of about $3.5\times10^{10}$ protons that were extracted over 101.5\,ms-long spills. The radiation environment was characterized by CZT and plastic scintillator counters. Preliminary results indicate that the PET technology used in our tests can efficiently record FLASH beam events. The instrument yielded informative and quantitative imaging and dosimetry of beam-activated isotopes in a PMMA phantoms, as supported by Monte Carlo simulations. These studies open a new PET modality that can lead to improved imaging and monitoring of FLASH proton therapy.

Keyword(s): FLASH beam ; PET ; PET dosimetry ; PET imaging ; proton therapy ; radiation oncology ; radiation treatment plan

Note: Phys. Med. Biol. 68 (2023) 125001

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Contributing Institute(s):

1. E041 Med. Physik in der Radioonkologie (E041)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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