Journal Article

DKFZ-2023-00931

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png CEST Imaging of the APT and ssMT predict the overall survival of patients with glioma at the first follow-up after completion of radiotherapy at 3T.

Knebel Doeberitz, N. V. (First author)DKFZ* ; Kroh, F.DKFZ* ; Breitling, J.DKFZ* ; König, L. ; Maksimovic, S.DKFZ* ; Graß, S.DKFZ* ; Adeberg, S. ; Scherer, M. ; Unterberg, A. ; Bendszus, M. ; Wick, W. ; Bachert, P.DKFZ* ; Debus, J.DKFZ* ; Ladd, M. E.DKFZ* ; Schlemmer, H.-P.DKFZ* ; Korzowski, A.DKFZ* ; Goerke, S.DKFZ* ; Paech, D. (Last author)DKFZ*

2023
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.radonc.2023.109694

Abstract: Outcome prediction of patients with glioma early after the completion of radiotherapy represents a major clinical challenge. Previously, the prognostic value of chemical exchange saturation transfer (CEST) imaging has been demonstrated in patients with newly diagnosed glioma. The objective of this study was to assess the potential of amide proton transfer (APT)-, relayed nuclear Overhauser effect (rNOE)- and semi-solid magnetization transfer (ssMT)-imaging according to Zhou et al. (APTwasym), Goerke et al. (MTRRexAPT, MTRRexNOE and MTRRexMT) and Mehrabian et al. (PeakAreaAPT, PeakAreaNOE and MTconst) for the prognostication of the overall survival (OS) of patients with glioma at the first follow-up after the completion of radiotherapy.49 of 72 participants with diffuse glioma, who underwent CEST MRI at 3T between July 2018 and December 2021 4 to 6 weeks after the completion of radiotherapy, were analyzed. Contrast-enhancing tumor (CE) and whole tumor (WT) volumes were segmented on T2w-FLAIR and contrast-enhanced T1w images. Kaplan-Meier analysis and logrank-test were used for statistical analyses.APTw imaging demonstrated the strongest association with OS (HR=4.66, p<0.001). The MTconst (HR=2.54, p=0.044) was associated with the OS of participants with residual contrast-enhancing glioma tissue, whilst the MTRRexAPT (HR=2.44, p=0.056) showed a trend in this sub-cohort. The MTRRexNOE, MTRRexMT and PeakAreaNOE were not associated with survival.Imaging of the APT and ssMT at the first follow-up 4 to 6 weeks after the completion of radiotherapy at 3T were associated with the overall survival of patients with glioma.

Keyword(s): Chemical exchange saturation transfer MRI ; amide proton transfer ; glioma ; overall survival ; radiotherapy ; semi-solid magnetization transfer

Note: #EA:E010#LA:E010# / 2023 Jul;184:109694

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Contributing Institute(s):

1. E010 Radiologie (E010)
2. E020 Med. Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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