% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Kubik:276068,
      author       = {A. Kubik and I. P. A. das Virgens and A. Szabó and M.
                      Váradi and A. Csizmarik and A. Keszthelyi and A. Majoros
                      and P. Fehérvári and P. Hegyi and N. Ács and P. Nyirády
                      and T. Szarvas$^*$},
      title        = {{C}omprehensive {A}nalysis of the {P}rognostic {V}alue of
                      {C}irculating {MMP}-7 {L}evels in {U}rothelial {C}arcinoma:
                      {A} {C}ombined {C}ohort {A}nalysis, {S}ystematic {R}eview,
                      and {M}eta-{A}nalysis.},
      journal      = {International journal of molecular sciences},
      volume       = {24},
      number       = {9},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DKFZ-2023-00974},
      pages        = {7859},
      year         = {2023},
      abstract     = {Lymph node (LN) status is the most significant prognostic
                      factor for invasive urothelial bladder cancer (UBC);
                      however, the optimal extent of LN dissection (LND) is
                      debated. We assessed circulating matrix metalloproteinase-7
                      (MMP-7) as a prognostic factor and decision-making marker
                      for the extent of LND. Preoperative serum MMP-7 levels were
                      determined in two independent UBC cohorts (n = 188; n = 68)
                      and in one control cohort (n = 97) by using the ELISA
                      method. A systematic review and meta-analysis on the
                      prognostic role of circulating pretreatment MMP-7 levels
                      were performed. Serum MMP-7 levels were higher in patients
                      compared to controls (p < 0.001) with the highest levels in
                      LN-positive cases. Half of LN-positive UBC patients had low
                      MMP-7 levels, whereas the survival of LN-negative patients
                      with high serum MMP-7 findings was poor. MMP-7 levels were
                      independently associated with poor survival in both cohorts
                      (p = 0.006, p < 0.001). Accordingly, our systematic review
                      of six eligible publications revealed a 2.5-fold higher
                      mortality risk in patients with high MMP-7 levels. In
                      conclusion, preoperative MMP-7 level is a validated and
                      independent prognostic factor in urothelial cancer. It
                      cannot be used to decide between regional or extended LND
                      but may be useful in identifying LN-negative high-risk
                      patients with potentially undetected metastases.},
      subtyp        = {Review Article},
      keywords     = {Humans / Carcinoma, Transitional Cell / Urinary Bladder
                      Neoplasms: pathology / Matrix Metalloproteinase 7 /
                      Prognosis / Cystectomy: methods / Cohort Studies / Lymph
                      Nodes: pathology / MMP-7 (Other) / biomarker (Other) /
                      lymphadenectomy (Other) / matrilysin (Other) /
                      micrometastases (Other) / overall survival (Other) /
                      prognostication (Other) / radical cystectomy (Other) /
                      urinary bladder cancer (Other) / urothelial cancer (Other) /
                      Matrix Metalloproteinase 7 (NLM Chemicals)},
      cin          = {ED01},
      ddc          = {540},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37175566},
      pmc          = {pmc:PMC10178327},
      doi          = {10.3390/ijms24097859},
      url          = {https://inrepo02.dkfz.de/record/276068},
}