Journal Article (Review Article)

DKFZ-2023-00974

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Comprehensive Analysis of the Prognostic Value of Circulating MMP-7 Levels in Urothelial Carcinoma: A Combined Cohort Analysis, Systematic Review, and Meta-Analysis.

Kubik, A. ; das Virgens, I. P. A. ; Szabó, A. ; Váradi, M. ; Csizmarik, A. ; Keszthelyi, A. ; Majoros, A. ; Fehérvári, P. ; Hegyi, P. ; Ács, N. ; Nyirády, P. ; Szarvas, T.DKFZ*

2023
Molecular Diversity Preservation International Basel

This record in other databases:  

Please use a persistent id in citations: doi:10.3390/ijms24097859

Abstract: Lymph node (LN) status is the most significant prognostic factor for invasive urothelial bladder cancer (UBC); however, the optimal extent of LN dissection (LND) is debated. We assessed circulating matrix metalloproteinase-7 (MMP-7) as a prognostic factor and decision-making marker for the extent of LND. Preoperative serum MMP-7 levels were determined in two independent UBC cohorts (n = 188; n = 68) and in one control cohort (n = 97) by using the ELISA method. A systematic review and meta-analysis on the prognostic role of circulating pretreatment MMP-7 levels were performed. Serum MMP-7 levels were higher in patients compared to controls (p < 0.001) with the highest levels in LN-positive cases. Half of LN-positive UBC patients had low MMP-7 levels, whereas the survival of LN-negative patients with high serum MMP-7 findings was poor. MMP-7 levels were independently associated with poor survival in both cohorts (p = 0.006, p < 0.001). Accordingly, our systematic review of six eligible publications revealed a 2.5-fold higher mortality risk in patients with high MMP-7 levels. In conclusion, preoperative MMP-7 level is a validated and independent prognostic factor in urothelial cancer. It cannot be used to decide between regional or extended LND but may be useful in identifying LN-negative high-risk patients with potentially undetected metastases.

Keyword(s): Humans (MeSH) ; Carcinoma, Transitional Cell (MeSH) ; Urinary Bladder Neoplasms: pathology (MeSH) ; Matrix Metalloproteinase 7 (MeSH) ; Prognosis (MeSH) ; Cystectomy: methods (MeSH) ; Cohort Studies (MeSH) ; Lymph Nodes: pathology (MeSH) ; MMP-7 ; biomarker ; lymphadenectomy ; matrilysin ; micrometastases ; overall survival ; prognostication ; radical cystectomy ; urinary bladder cancer ; urothelial cancer ; Matrix Metalloproteinase 7

---

Contributing Institute(s):

1. DKTK ED ES zentral (ED01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

---

Database coverage:
; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---