%0 Journal Article
%A Gudenkauf, Lisa M
%A Chavez, Melody N
%A Maconi, Melinda Leigh
%A Geiss, Carley
%A Seyedroudbari, Ameen
%A Thin, Pan
%A Hoogland, Aasha I
%A Nguyen, Kathleen
%A Murthy, Vishnu
%A Armstrong, Wesley R
%A Komrokji, Khaled
%A Oswald, Laura B
%A Jim, Heather S L
%A El-Haddad, Ghassan
%A Fendler, Wolfgang P
%A Herrmann, Ken
%A Cella, David
%A Czernin, Johannes
%A Hofman, Michael S
%A Dicker, Adam P
%A Calais, Jeremie
%A Tagawa, Scott T
%A Gonzalez, Brian D
%T Developing a Patient-Reported Outcome Measure for Radionuclide Therapy for Prostate Cancer.
%J Journal of nuclear medicine
%V 64
%N 6
%@ 0097-9058
%C New York, NY
%I Soc.
%M DKFZ-2023-01098
%P 869 - 872
%D 2023
%X The field of radionuclide therapy (RNT) for prostate cancer (PC) is growing rapidly, with recent Food and Drug Administration approval of the first 177Lu-PSMA ligand. We aimed to develop the first patient-reported outcome (PRO) measure for PC patients receiving RNT. Methods: We identified relevant symptoms and toxicities by reviewing published trials and interviews with PC patients receiving RNT (n = 29), caregivers (n = 14), and clinicians (n = 11). Second, we selected items for measure inclusion. Third, we refined the item list with input from experts in RNTs and PROs. Fourth, we finalized the Functional Assessment of Cancer Therapy-Radionuclide Therapy (FACT-RNT) with patient input. Results: This multistep process yielded a brief 15-item measure deemed by key stakeholders to be relevant and useful in the context of RNT for PC. Conclusion: The FACT-RNT is a new standardized tool to monitor relevant symptoms and toxicities among PC patients in RNT trials and real-world settings.
%K Male
%K Humans
%K Prostatic Neoplasms: radiotherapy
%K Prostatic Neoplasms: drug therapy
%K Radioisotopes: therapeutic use
%K Patient Reported Outcome Measures
%K genitourinary oncology (Other)
%K patient-reported outcomes (Other)
%K prostate cancer (Other)
%K radionuclide therapy (Other)
%K radiopharmaceuticals (Other)
%K Radioisotopes (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36635088
%R 10.2967/jnumed.122.264946
%U https://inrepo02.dkfz.de/record/276415