Journal Article

DKFZ-2023-01098

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Developing a Patient-Reported Outcome Measure for Radionuclide Therapy for Prostate Cancer.

Gudenkauf, L. M. ; Chavez, M. N. ; Maconi, M. L. ; Geiss, C. ; Seyedroudbari, A. ; Thin, P. ; Hoogland, A. I. ; Nguyen, K. ; Murthy, V. ; Armstrong, W. R. ; Komrokji, K. ; Oswald, L. B. ; Jim, H. S. L. ; El-Haddad, G. ; Fendler, W. P.DKFZ* ; Herrmann, K.DKFZ* ; Cella, D. ; Czernin, J. ; Hofman, M. S. ; Dicker, A. P. ; Calais, J. ; Tagawa, S. T. ; Gonzalez, B. D.

2023
Soc. New York, NY

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Please use a persistent id in citations: doi:10.2967/jnumed.122.264946

Abstract: The field of radionuclide therapy (RNT) for prostate cancer (PC) is growing rapidly, with recent Food and Drug Administration approval of the first 177Lu-PSMA ligand. We aimed to develop the first patient-reported outcome (PRO) measure for PC patients receiving RNT. Methods: We identified relevant symptoms and toxicities by reviewing published trials and interviews with PC patients receiving RNT (n = 29), caregivers (n = 14), and clinicians (n = 11). Second, we selected items for measure inclusion. Third, we refined the item list with input from experts in RNTs and PROs. Fourth, we finalized the Functional Assessment of Cancer Therapy-Radionuclide Therapy (FACT-RNT) with patient input. Results: This multistep process yielded a brief 15-item measure deemed by key stakeholders to be relevant and useful in the context of RNT for PC. Conclusion: The FACT-RNT is a new standardized tool to monitor relevant symptoms and toxicities among PC patients in RNT trials and real-world settings.

Keyword(s): Male (MeSH) ; Humans (MeSH) ; Prostatic Neoplasms: radiotherapy (MeSH) ; Prostatic Neoplasms: drug therapy (MeSH) ; Radioisotopes: therapeutic use (MeSH) ; Patient Reported Outcome Measures (MeSH) ; genitourinary oncology ; patient-reported outcomes ; prostate cancer ; radionuclide therapy ; radiopharmaceuticals ; Radioisotopes

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Contributing Institute(s):

1. DKTK ED ES zentral (ED01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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