TY  - JOUR
AU  - Gudenkauf, Lisa M
AU  - Chavez, Melody N
AU  - Maconi, Melinda Leigh
AU  - Geiss, Carley
AU  - Seyedroudbari, Ameen
AU  - Thin, Pan
AU  - Hoogland, Aasha I
AU  - Nguyen, Kathleen
AU  - Murthy, Vishnu
AU  - Armstrong, Wesley R
AU  - Komrokji, Khaled
AU  - Oswald, Laura B
AU  - Jim, Heather S L
AU  - El-Haddad, Ghassan
AU  - Fendler, Wolfgang P
AU  - Herrmann, Ken
AU  - Cella, David
AU  - Czernin, Johannes
AU  - Hofman, Michael S
AU  - Dicker, Adam P
AU  - Calais, Jeremie
AU  - Tagawa, Scott T
AU  - Gonzalez, Brian D
TI  - Developing a Patient-Reported Outcome Measure for Radionuclide Therapy for Prostate Cancer.
JO  - Journal of nuclear medicine
VL  - 64
IS  - 6
SN  - 0097-9058
CY  - New York, NY
PB  - Soc.
M1  - DKFZ-2023-01098
SP  - 869 - 872
PY  - 2023
AB  - The field of radionuclide therapy (RNT) for prostate cancer (PC) is growing rapidly, with recent Food and Drug Administration approval of the first 177Lu-PSMA ligand. We aimed to develop the first patient-reported outcome (PRO) measure for PC patients receiving RNT. Methods: We identified relevant symptoms and toxicities by reviewing published trials and interviews with PC patients receiving RNT (n = 29), caregivers (n = 14), and clinicians (n = 11). Second, we selected items for measure inclusion. Third, we refined the item list with input from experts in RNTs and PROs. Fourth, we finalized the Functional Assessment of Cancer Therapy-Radionuclide Therapy (FACT-RNT) with patient input. Results: This multistep process yielded a brief 15-item measure deemed by key stakeholders to be relevant and useful in the context of RNT for PC. Conclusion: The FACT-RNT is a new standardized tool to monitor relevant symptoms and toxicities among PC patients in RNT trials and real-world settings.
KW  - Male
KW  - Humans
KW  - Prostatic Neoplasms: radiotherapy
KW  - Prostatic Neoplasms: drug therapy
KW  - Radioisotopes: therapeutic use
KW  - Patient Reported Outcome Measures
KW  - genitourinary oncology (Other)
KW  - patient-reported outcomes (Other)
KW  - prostate cancer (Other)
KW  - radionuclide therapy (Other)
KW  - radiopharmaceuticals (Other)
KW  - Radioisotopes (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:36635088
DO  - DOI:10.2967/jnumed.122.264946
UR  - https://inrepo02.dkfz.de/record/276415
ER  -