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000276873 1001_ $$0P:(DE-He78)755f822fc93d192ba70eec0af8eb4809$$aSchäfer, Miriam$$b0$$eFirst author$$udkfz
000276873 245__ $$aSpatial tissue proteomics reveals distinct landscapes of heterogeneity in cutaneous papillomavirus-induced keratinocyte carcinomas.
000276873 260__ $$aBognor Regis [u.a.]$$bWiley$$c2023
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000276873 520__ $$aInfection with certain cutaneous human papillomaviruses (HPV), in conjunction with chronic ultraviolet (UV) exposure, are the major cofactors of non-melanoma skin cancer (NMSC), the most frequent cancer type worldwide. Cutaneous squamous cell carcinomas (SCCs) as well as tumors in general represent three-dimensional entities determined by both temporal and spatial constraints. Whole tissue proteomics is a straightforward approach to understand tumorigenesis in better detail, but studies focusing on different progression states toward a dedifferentiated SCC phenotype on a spatial level are rare. Here, we applied an innovative proteomic workflow on formalin-fixed, paraffin-embedded (FFPE) epithelial tumors derived from the preclinical animal model Mastomys coucha. This rodent is naturally infected with its genuine cutaneous papillomavirus and closely mimics skin carcinogenesis in the context of cutaneous HPV infections in humans. We deciphered cellular networks by comparing diverse epithelial tissues with respect to their differentiation level and infection status. Our study reveals novel regulatory proteins and pathways associated with virus-induced tumor initiation and progression of SCCs. This approach provides the basis to better comprehend the multistep process of skin carcinogenesis.
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000276873 650_7 $$2Other$$aMastomys coucha
000276873 650_7 $$2Other$$aMnPV
000276873 650_7 $$2Other$$acutaneous papillomavirus
000276873 650_7 $$2Other$$ain vivo proteomics
000276873 650_7 $$2Other$$anon-melanoma skin cancer (NMSC)
000276873 7001_ $$0P:(DE-He78)0d37cc734b95fed555f2244d6fee6320$$aSchneider, Martin$$b1$$udkfz
000276873 7001_ $$0P:(DE-He78)f0c2bd6811990c0fd74ffcd3f59d9712$$aMüller, Torsten$$b2
000276873 7001_ $$0P:(DE-He78)d608dee733b60fb66f0235c436718a05$$aFranz, Natascha$$b3$$udkfz
000276873 7001_ $$0P:(DE-He78)810ef819c7d86928b119192db5730fc7$$aBraspenning-Wesch, Ilona$$b4$$udkfz
000276873 7001_ $$0P:(DE-He78)fd869847d6731bf306dce72ed1ef343b$$aStephan, Sonja$$b5$$udkfz
000276873 7001_ $$aSchmidt, Gabriele$$b6
000276873 7001_ $$0P:(DE-He78)939d5891259c638c1ab053b1456a578c$$aKrijgsveld, Jeroen$$b7$$udkfz
000276873 7001_ $$0P:(DE-He78)daaed5a5b968028e6e95d273150d5ab1$$aHelm, Dominic$$b8$$udkfz
000276873 7001_ $$0P:(DE-He78)97f27961503f8b3233697cbad1bbed4e$$aRösl, Frank$$b9$$udkfz
000276873 7001_ $$0P:(DE-He78)93b84588571c05b85df1c0916f740e98$$aHasche, Daniel$$b10$$eLast author$$udkfz
000276873 773__ $$0PERI:(DE-600)1475090-9$$a10.1002/jmv.28850$$gVol. 95, no. 6, p. e28850$$n6$$pe28850$$tJournal of medical virology$$v95$$x0146-6615$$y2023
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