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@ARTICLE{Schfer:276873,
      author       = {M. Schäfer$^*$ and M. Schneider$^*$ and T. Müller$^*$ and
                      N. Franz$^*$ and I. Braspenning-Wesch$^*$ and S. Stephan$^*$
                      and G. Schmidt and J. Krijgsveld$^*$ and D. Helm$^*$ and F.
                      Rösl$^*$ and D. Hasche$^*$},
      title        = {{S}patial tissue proteomics reveals distinct landscapes of
                      heterogeneity in cutaneous papillomavirus-induced
                      keratinocyte carcinomas.},
      journal      = {Journal of medical virology},
      volume       = {95},
      number       = {6},
      issn         = {0146-6615},
      address      = {Bognor Regis [u.a.]},
      publisher    = {Wiley},
      reportid     = {DKFZ-2023-01182},
      pages        = {e28850},
      year         = {2023},
      note         = {#EA:F030#LA:F030#},
      abstract     = {Infection with certain cutaneous human papillomaviruses
                      (HPV), in conjunction with chronic ultraviolet (UV)
                      exposure, are the major cofactors of non-melanoma skin
                      cancer (NMSC), the most frequent cancer type worldwide.
                      Cutaneous squamous cell carcinomas (SCCs) as well as tumors
                      in general represent three-dimensional entities determined
                      by both temporal and spatial constraints. Whole tissue
                      proteomics is a straightforward approach to understand
                      tumorigenesis in better detail, but studies focusing on
                      different progression states toward a dedifferentiated SCC
                      phenotype on a spatial level are rare. Here, we applied an
                      innovative proteomic workflow on formalin-fixed,
                      paraffin-embedded (FFPE) epithelial tumors derived from the
                      preclinical animal model Mastomys coucha. This rodent is
                      naturally infected with its genuine cutaneous papillomavirus
                      and closely mimics skin carcinogenesis in the context of
                      cutaneous HPV infections in humans. We deciphered cellular
                      networks by comparing diverse epithelial tissues with
                      respect to their differentiation level and infection status.
                      Our study reveals novel regulatory proteins and pathways
                      associated with virus-induced tumor initiation and
                      progression of SCCs. This approach provides the basis to
                      better comprehend the multistep process of skin
                      carcinogenesis.},
      keywords     = {Mastomys coucha (Other) / MnPV (Other) / cutaneous
                      papillomavirus (Other) / in vivo proteomics (Other) /
                      non-melanoma skin cancer (NMSC) (Other)},
      cin          = {F030 / W120 / B230 / W210},
      ddc          = {610},
      cid          = {I:(DE-He78)F030-20160331 / I:(DE-He78)W120-20160331 /
                      I:(DE-He78)B230-20160331 / I:(DE-He78)W210-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37322807},
      doi          = {10.1002/jmv.28850},
      url          = {https://inrepo02.dkfz.de/record/276873},
}