Journal Article

DKFZ-2023-01301

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Population-Attributable Fractions of Personal Comorbidities for Liver, Gallbladder, and Bile Duct Cancers.

Hemminki, K. (First author)DKFZ* ; Sundquist, K. ; Sundquist, J. ; Försti, A.DKFZ* ; Liska, V. ; Hemminki, A. ; Li, X.

2023
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/cancers15123092

Abstract: We aim to estimate population-attributable fractions (PAF) for 13 comorbidities potentially predisposing to hepatobiliary cancer of hepatocellular carcinoma (HCC), gallbladder cancer (GBC), cancers of the intrahepatic and extrahepatic bile ducts (ICC and ECC), and ampullary cancer.Patients were identified from the Swedish Inpatient Register from 1987 to 2018 and cancers from the Swedish Cancer Registry from 1997 through 2018. PAFs were calculated for each comorbidity-associated cancer using a cohort study design.For male HCC, the major individual comorbidities (PAF > 10) were diabetes, alcohol-related liver disease, and hepatitis C virus infection. For female HCC, diabetes and autoimmune diseases were important contributors. For female GBC, gallstone disease was an overwhelming contributor, with a PAF of 30.57%, which was also important for men. The overall PAF for male ICC was almost two times higher than the female one. For ECC and ampullary cancer, infection of bile ducts was associated with the highest PAF.The 13 comorbidities accounted for 50% or more of the potential etiological pathways of each hepatobiliary cancer except female ICC. The underlying convergent mechanism for these cancers may be chronic inflammation lasting for decades and thus offering possibilities for intervention and disease monitoring.

Keyword(s): alcohol ; bile duct infection ; comorbidity ; hepatocellular carcinoma ; risk factor ; viral infection

Note: #EA:C020#

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)
2. B062 Pädiatrische Neuroonkologie (B062)
3. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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