Journal Article

DKFZ-2023-01334

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Prognostic biomarkers for survival in mucosal melanoma.

Thierauf, J. C. (First author)DKFZ* ; Kaluziak, S. T. ; Codd, E. ; Dybel, S. N. ; Jobbagy, S. ; Purohit, R. ; Farahani, A. A. ; Dedeilia, A. ; Naranbhai, V. ; Hoang, M. P. ; Fisch, A. S. ; Ritterhouse, L. ; Boland, G. M. ; Lennerz, J. K. ; Iafrate, A. J.

2023
Wiley-Blackwell Oxford [u.a.]

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Please use a persistent id in citations: doi:10.1111/pcmr.13104

Abstract: Mucosal melanoma (MM) is a rare subtype of melanoma with an aggressive clinical course. In cutaneous melanoma (CM), the absence of pigmentation and presence of NRAS/KRAS mutations are biomarkers indicating an aggressive clinical course with shorter overall survival. Similar data for MM are missing. We present the real-world outcome data in a cohort of genotyped MM patients and assessed the prognostic relevance of pigmentation- and NRAS/KRAS mutation status. We correlated pathological reports and clinical data with overall survival of patients with MM. Furthermore, we performed clinically integrated molecular genotyping and analyzed real world treatment regimens for covariates associated with clinical outcome. We identified 39 patients with available clinical and molecular data. Patients with amelanotic MM had a significantly shorter overall survival (p = .003). In addition, the presence of a NRAS or KRAS mutation was significantly associated with poor overall survival (NRAS or KRAS p = .024). Currently, it is unknown if the same prognostic relevance for the lack of pigmentation and RAS mutations in CM, exists in MM. Here we analyzed a cohort of MM for outcome measures and determined that two known prognostic biomarkers for CM are in fact novel prognosticators for MM.

Keyword(s): genotyping ; mucosal melanoma ; pigmentation ; prognostic biomarkers

Note: #EA:A102# / 2023 Sep;36(5):378-387

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Contributing Institute(s):

1. Molekulare Grundlagen von HNO-Tumoren (A102)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2023

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; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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