%0 Journal Article
%A de Maissin, Henri
%A Groß, Philipp R
%A Mohiuddin, Obaid
%A Weigt, Moritz
%A Nagel, Luca
%A Herzog, Marvin
%A Wang, Zirun
%A Willing, Robert
%A Reichardt, Wilfried
%A Pichotka, Martin
%A Heß, Lisa
%A Reinheckel, Thomas
%A Jessen, Henning J
%A Zeiser, Robert
%A Bock, Michael
%A von Elverfeldt, Dominik
%A Zaitsev, Maxim
%A Korchak, Sergey
%A Glöggler, Stefan
%A Hövener, Jan-Bernd
%A Chekmenev, Eduard Y
%A Schilling, Franz
%A Knecht, Stephan
%A Schmidt, Andreas
%T In Vivo Metabolic Imaging of [1-13C]Pyruvate-d3 Hyperpolarized By Reversible Exchange With Parahydrogen.
%J Angewandte Chemie / International edition
%V 62
%N 36
%@ 1433-7851
%C Weinheim
%I Wiley-VCH
%M DKFZ-2023-01399
%P e202306654
%D 2023
%Z 2023 Sep 4;62(36):e202306654
%X Metabolic magnetic resonance imaging (MRI) using hyperpolarized (HP) pyruvate is becoming a non-invasive technique for diagnosing, staging, and monitoring response to treatment in cancer and other diseases. The clinically established method for producing HP pyruvate, dissolution dynamic nuclear polarization, however, is rather complex and slow. Signal Amplification By Reversible Exchange (SABRE) is an ultra-fast and low-cost method based on fast chemical exchange. Here, for the first time, we demonstrate not only in vivo utility, but also metabolic MRI with SABRE. We present a novel routine to produce aqueous HP [1-13C]pyruvate-d3 for injection in 6 minutes. The injected solution was sterile, non-toxic, pH neutral and contained ≈30 mM [1-13C]pyruvate-d3 polarized to ≈11
%K SABRE (Other)
%K hyperpolarization (Other)
%K metabolic imaging (Other)
%K parahydrogen (Other)
%K pyruvate (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37439488
%R 10.1002/anie.202306654
%U https://inrepo02.dkfz.de/record/277486