Journal Article

DKFZ-2023-01399

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png In Vivo Metabolic Imaging of [1-13C]Pyruvate-d3 Hyperpolarized By Reversible Exchange With Parahydrogen.

de Maissin, H.DKFZ* ; Groß, P. R. ; Mohiuddin, O. ; Weigt, M. ; Nagel, L. ; Herzog, M. ; Wang, Z. ; Willing, R.DKFZ* ; Reichardt, W. ; Pichotka, M. ; Heß, L. ; Reinheckel, T.DKFZ* ; Jessen, H. J. ; Zeiser, R.DKFZ* ; Bock, M. ; von Elverfeldt, D. ; Zaitsev, M. ; Korchak, S. ; Glöggler, S. ; Hövener, J.-B. ; Chekmenev, E. Y. ; Schilling, F.DKFZ* ; Knecht, S. ; Schmidt, A.DKFZ*

2023
Wiley-VCH Weinheim

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Please use a persistent id in citations: doi:10.1002/anie.202306654

Abstract: Metabolic magnetic resonance imaging (MRI) using hyperpolarized (HP) pyruvate is becoming a non-invasive technique for diagnosing, staging, and monitoring response to treatment in cancer and other diseases. The clinically established method for producing HP pyruvate, dissolution dynamic nuclear polarization, however, is rather complex and slow. Signal Amplification By Reversible Exchange (SABRE) is an ultra-fast and low-cost method based on fast chemical exchange. Here, for the first time, we demonstrate not only in vivo utility, but also metabolic MRI with SABRE. We present a novel routine to produce aqueous HP [1-13C]pyruvate-d3 for injection in 6 minutes. The injected solution was sterile, non-toxic, pH neutral and contained ≈30 mM [1-13C]pyruvate-d3 polarized to ≈11% (residual 250 mM methanol and 20 µM catalyst). It was obtained by rapid solvent evaporation and metal filtering, which we detail in this manuscript. This achievement makes HP pyruvate MRI available to a wide biomedical community for fast metabolic imaging of living organisms.

Keyword(s): SABRE ; hyperpolarization ; metabolic imaging ; parahydrogen ; pyruvate

Note: 2023 Sep 4;62(36):e202306654

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Freiburg (FR01)
2. DKTK Koordinierungsstelle München (MU01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2023

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Database coverage:
; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; Index Chemicus ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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