TY  - JOUR
AU  - de Maissin, Henri
AU  - Groß, Philipp R
AU  - Mohiuddin, Obaid
AU  - Weigt, Moritz
AU  - Nagel, Luca
AU  - Herzog, Marvin
AU  - Wang, Zirun
AU  - Willing, Robert
AU  - Reichardt, Wilfried
AU  - Pichotka, Martin
AU  - Heß, Lisa
AU  - Reinheckel, Thomas
AU  - Jessen, Henning J
AU  - Zeiser, Robert
AU  - Bock, Michael
AU  - von Elverfeldt, Dominik
AU  - Zaitsev, Maxim
AU  - Korchak, Sergey
AU  - Glöggler, Stefan
AU  - Hövener, Jan-Bernd
AU  - Chekmenev, Eduard Y
AU  - Schilling, Franz
AU  - Knecht, Stephan
AU  - Schmidt, Andreas
TI  - In Vivo Metabolic Imaging of [1-13C]Pyruvate-d3 Hyperpolarized By Reversible Exchange With Parahydrogen.
JO  - Angewandte Chemie / International edition
VL  - 62
IS  - 36
SN  - 1433-7851
CY  - Weinheim
PB  - Wiley-VCH
M1  - DKFZ-2023-01399
SP  - e202306654
PY  - 2023
N1  - 2023 Sep 4;62(36):e202306654
AB  - Metabolic magnetic resonance imaging (MRI) using hyperpolarized (HP) pyruvate is becoming a non-invasive technique for diagnosing, staging, and monitoring response to treatment in cancer and other diseases. The clinically established method for producing HP pyruvate, dissolution dynamic nuclear polarization, however, is rather complex and slow. Signal Amplification By Reversible Exchange (SABRE) is an ultra-fast and low-cost method based on fast chemical exchange. Here, for the first time, we demonstrate not only in vivo utility, but also metabolic MRI with SABRE. We present a novel routine to produce aqueous HP [1-13C]pyruvate-d3 for injection in 6 minutes. The injected solution was sterile, non-toxic, pH neutral and contained ≈30 mM [1-13C]pyruvate-d3 polarized to ≈11
KW  - SABRE (Other)
KW  - hyperpolarization (Other)
KW  - metabolic imaging (Other)
KW  - parahydrogen (Other)
KW  - pyruvate (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37439488
DO  - DOI:10.1002/anie.202306654
UR  - https://inrepo02.dkfz.de/record/277486
ER  -