% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{deMaissin:277486,
      author       = {H. de Maissin$^*$ and P. R. Groß and O. Mohiuddin and M.
                      Weigt and L. Nagel and M. Herzog and Z. Wang and R.
                      Willing$^*$ and W. Reichardt and M. Pichotka and L. Heß and
                      T. Reinheckel$^*$ and H. J. Jessen and R. Zeiser$^*$ and M.
                      Bock and D. von Elverfeldt and M. Zaitsev and S. Korchak and
                      S. Glöggler and J.-B. Hövener and E. Y. Chekmenev and F.
                      Schilling$^*$ and S. Knecht and A. Schmidt$^*$},
      title        = {{I}n {V}ivo {M}etabolic {I}maging of [1-13{C}]{P}yruvate-d3
                      {H}yperpolarized {B}y {R}eversible {E}xchange {W}ith
                      {P}arahydrogen.},
      journal      = {Angewandte Chemie / International edition},
      volume       = {62},
      number       = {36},
      issn         = {1433-7851},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {DKFZ-2023-01399},
      pages        = {e202306654},
      year         = {2023},
      note         = {2023 Sep 4;62(36):e202306654},
      abstract     = {Metabolic magnetic resonance imaging (MRI) using
                      hyperpolarized (HP) pyruvate is becoming a non-invasive
                      technique for diagnosing, staging, and monitoring response
                      to treatment in cancer and other diseases. The clinically
                      established method for producing HP pyruvate, dissolution
                      dynamic nuclear polarization, however, is rather complex and
                      slow. Signal Amplification By Reversible Exchange (SABRE) is
                      an ultra-fast and low-cost method based on fast chemical
                      exchange. Here, for the first time, we demonstrate not only
                      in vivo utility, but also metabolic MRI with SABRE. We
                      present a novel routine to produce aqueous HP
                      [1-13C]pyruvate-d3 for injection in 6 minutes. The injected
                      solution was sterile, non-toxic, pH neutral and contained
                      ≈30 mM [1-13C]pyruvate-d3 polarized to $≈11\%$ (residual
                      250 mM methanol and 20 µM catalyst). It was obtained by
                      rapid solvent evaporation and metal filtering, which we
                      detail in this manuscript. This achievement makes HP
                      pyruvate MRI available to a wide biomedical community for
                      fast metabolic imaging of living organisms.},
      keywords     = {SABRE (Other) / hyperpolarization (Other) / metabolic
                      imaging (Other) / parahydrogen (Other) / pyruvate (Other)},
      cin          = {FR01 / MU01},
      ddc          = {540},
      cid          = {I:(DE-He78)FR01-20160331 / I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37439488},
      doi          = {10.1002/anie.202306654},
      url          = {https://inrepo02.dkfz.de/record/277486},
}